Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 14/20 | 0.80 |
| ▸ | BRAF | P15056 | 5/20 | 0.53 |
| ▸ | RAF1 | P04049 | 4/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10268807 | 0.91 | KARS1 (0.68) | KARS1BRAF | |
| SCHEMBL902092 | 0.91 | KARS1 (0.68) | KARS1BRAFRAF1ALOX15TSHR | |
| SCHEMBL902055 | 0.89 | KARS1 (0.88) | KARS1 | |
| SCHEMBL901763 | 0.89 | KARS1 (1.00) | KARS1 | |
| SCHEMBL902653 | 0.89 | KARS1 (0.80) | KARS1BRAFRAF1 | |
| SCHEMBL901742 | 0.89 | KARS1 (1.00) | KARS1 | |
| SCHEMBL901750 | 0.87 | KARS1 (0.81) | KARS1 | |
| SCHEMBL1704625 | 0.87 | KARS1 (0.61) | KARS1BRAFRAF1ALOX15TSHR | |
| SCHEMBL901595 | 0.86 | KARS1 (0.86) | KARS1 | |
| SCHEMBL1704268 | 0.86 | KARS1 (1.00) | KARS1BRAFRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | claimed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |