Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 11/20 | 0.61 |
| ▸ | RAF1 | P04049 | 5/20 | 0.48 |
| ▸ | BRAF | P15056 | 5/20 | 0.48 |
| ▸ | SYK | P43405 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902673 | 0.91 | KARS1 (0.65) | KARS1SYK | |
| SCHEMBL1704267 | 0.91 | KARS1 (0.63) | KARS1RAF1BRAFSYK | |
| SCHEMBL1704251 | 0.91 | KARS1 (0.73) | KARS1SYK | |
| SCHEMBL903001 | 0.91 | KARS1 (0.62) | KARS1SYK | |
| SCHEMBL902092 | 0.90 | KARS1 (0.68) | KARS1RAF1BRAFALOX15TSHR | |
| SCHEMBL1705312 | 0.90 | KARS1 (0.73) | KARS1SYK | |
| SCHEMBL1704893 | 0.90 | KARS1 (0.61) | KARS1SYK | |
| SCHEMBL1704942 | 0.88 | KARS1 (0.64) | KARS1RAF1BRAFSYK | |
| SCHEMBL1704600 | 0.88 | KARS1 (0.73) | KARS1RAF1BRAFSYK | |
| SCHEMBL1704596 | 0.88 | KARS1 (0.48) | KARS1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |