Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 17/20 | 0.74 |
| ▸ | BCL2 | P10415 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2208222 | 0.85 | MCL1 (1.00) | MCL1BCL2 | |
| SCHEMBL15622283 | 0.83 | MCL1 (0.96) | MCL1BCL2 | |
| SCHEMBL17044260 | 0.80 | MCL1 (0.56) | MCL1BCL2 | |
| SCHEMBL2203327 | 0.80 | MCL1 (0.78) | MCL1BCL2 | |
| SCHEMBL17044294 | 0.79 | MCL1 (0.75) | MCL1BCL2 | |
| SCHEMBL15622460 | 0.78 | MCL1 (0.75) | MCL1BCL2 | |
| SCHEMBL15625853 | 0.78 | MCL1 (0.96) | MCL1 | |
| SCHEMBL17044252 | 0.78 | MCL1 (0.74) | MCL1BCL2 | |
| SCHEMBL17044222 | 0.78 | MCL1 (0.54) | MCL1BCL2 | |
| SCHEMBL15625757 | 0.76 | MCL1 (1.00) | MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134685-B1 | 7-NONSUBSTITUTED INDOLE DERIVATIVES AS MCL-1 INHIBITORS | ABBVIE INC (US) | 2015-09-02 | — | — | EP | claimed |