Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 17/20 | 0.75 |
| ▸ | BCL2 | P10415 | 3/20 | 0.49 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.49 |
| ▸ | ALB | P02768 | 1/20 | 0.49 |
| ▸ | RXRA | P19793 | 3/20 | 0.43 |
| ▸ | RXRB | P28702 | 3/20 | 0.43 |
| ▸ | RXRG | P48443 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19178689 | 0.86 | MCL1 (0.77) | MCL1BCL2BCL2L1RXRARXRB | |
| SCHEMBL2207431 | 0.86 | MCL1 (1.00) | MCL1BCL2ALB | |
| SCHEMBL17044222 | 0.85 | MCL1 (0.54) | MCL1BCL2ALBRXRARXRB | |
| SCHEMBL15622406 | 0.84 | MCL1 (0.96) | MCL1BCL2ALB | |
| SCHEMBL19178595 | 0.83 | MCL1 (0.73) | MCL1BCL2BCL2L1RXRARXRB | |
| SCHEMBL17044347 | 0.82 | MCL1 (0.71) | MCL1BCL2BCL2L1ALB | |
| SCHEMBL19178670 | 0.81 | MCL1 (0.62) | MCL1BCL2ALB | |
| SCHEMBL2205708 | 0.80 | MCL1 (0.79) | MCL1BCL2ALB | |
| SCHEMBL19179197 | 0.80 | MCL1 (0.60) | MCL1BCL2BCL2L1ALB | |
| SCHEMBL17044286 | 0.79 | MCL1 (0.74) | MCL1BCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134685-B1 | 7-NONSUBSTITUTED INDOLE DERIVATIVES AS MCL-1 INHIBITORS | ABBVIE INC (US) | 2015-09-02 | — | — | EP | claimed |