Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPFFR2 | Q9Y5X5 | 3/20 | 0.60 |
| ▸ | NPFFR1 | Q9GZQ6 | 2/20 | 0.60 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.46 |
| ▸ | HTR3B | O95264 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.46 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17044396 | 1.00 | NPFFR2 (0.60) | NPFFR2NPFFR1HTR3EHTR3BHTR3A | |
| Hydrochloric Acid SCHEMBL5703221 | 0.99 | NPFFR2 (0.61) | NPFFR2NPFFR1HTR3EHTR3BHTR3A | |
| Hydrochloric Acid SCHEMBL5703225 | 0.99 | NPFFR2 (0.61) | NPFFR2NPFFR1HTR3EHTR3BHTR3A | |
| SCHEMBL16993676 | 0.84 | LMNA (0.44) | NPFFR2NPFFR1ALDH1A1LMNARECQL | |
| SCHEMBL16993675 | 0.84 | LMNA (0.44) | NPFFR2NPFFR1ALDH1A1LMNARECQL | |
| Hydrochloric Acid SCHEMBL6510408 | 0.83 | LMNA (0.43) | NPFFR2NPFFR1ALDH1A1LMNARECQL | |
| Hydrochloric Acid SCHEMBL6510411 | 0.83 | LMNA (0.43) | NPFFR2NPFFR1ALDH1A1LMNARECQL | |
| SCHEMBL17044425 | 0.83 | LMNA (0.46) | NPFFR2NPFFR1ALDH1A1LMNARECQL | |
| SCHEMBL17044426 | 0.83 | LMNA (0.46) | NPFFR2NPFFR1ALDH1A1LMNARECQL | |
| SCHEMBL7747051 | 0.82 | KMT2A (0.54) | NPFFR2ALDH1A1LMNAKDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150246140-A1 | COMPOSITIONS AND METHODS FOR MODULATING SLEEP AND WAKEFULNESS | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2015-09-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150246140-A1 | COMPOSITIONS AND METHODS FOR MODULATING SLEEP AND WAKEFULNESS | HCRTR2, HCRTR1, NPSR1 | NPFFR2 13/4885NPFFR1 17/4885HTR3E 195/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.