Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16188354 | 0.92 | ALDH1A1 (0.42) | CYP2C9MAPK1NPSR1ALDH1A1HCRTR1 | |
| SCHEMBL16309223 | 0.86 | HCRTR1 (0.49) | MEN1KMT2ACYP2C9MAPK1CYP1A2 | |
| SCHEMBL17044953 | 0.86 | HCRTR1 (0.49) | MEN1KMT2ACYP2C9MAPK1CYP1A2 | |
| SCHEMBL16309221 | 0.83 | KCNH2 (0.56) | MEN1KMT2ACYP2C9MAPK1CYP1A2 | |
| SCHEMBL17045001 | 0.83 | KMT2A (0.49) | MEN1KMT2ACYP2C9MAPK1CYP1A2 | |
| SCHEMBL22344943 | 0.82 | KCNH2 (0.59) | MEN1KMT2ACYP2C9MAPK1CYP1A2 | |
| SCHEMBL474884 | 0.82 | KCNH2 (0.49) | MEN1KMT2ACYP2C9MAPK1CYP1A2 | |
| SCHEMBL20952525 | 0.82 | KCNH2 (0.59) | MEN1KMT2ACYP2C9MAPK1CYP1A2 | |
| SCHEMBL22344937 | 0.82 | KCNH2 (0.49) | MEN1KMT2ACYP2C9MAPK1CYP1A2 | |
| SCHEMBL16188296 | 0.82 | KCNH2 (0.59) | MEN1KMT2ACYP2C9MAPK1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190127365-A1 | INHIBITORS OF HEPATITIS C VIRUS REPLICATION | MERCK SHARP & DOHME CORP. (US) | 2019-05-02 | — | — | US | disclosed |
| US-20150246917-A1 | INHIBITORS OF HEPATITIS C VIRUS REPLICATION | MERCK SHARP & DOHME CORP. (US) | 2015-09-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150246917-A1 | INHIBITORS OF HEPATITIS C VIRUS REPLICATION | HAVCR2, HCCS, EIF2AK2 | MEN1 4685/4885KMT2A 4309/4885CYP2C9 2551/4885 |
| US-20190127365-A1 | INHIBITORS OF HEPATITIS C VIRUS REPLICATION | HAVCR2, HCCS, EIF2AK2 | MEN1 4685/4885KMT2A 4309/4885CYP2C9 2551/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.