Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | XDH | P47989 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.30 |
| ▸ | TSHR | P16473 | 2/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18299825 | 0.80 | ALDH1A1 (0.36) | KDM4EALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL26345552 | 0.79 | CYP3A4 (0.47) | KDM4EALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL29579355 | 0.76 | CYP3A4 (0.38) | ALDH1A1CYP3A4MEN1MAPTHPGD | |
| SCHEMBL8543050 | 0.76 | CYP3A4 (0.38) | ALDH1A1CYP3A4MEN1MAPTHPGD | |
| SCHEMBL1984293 | 0.76 | ALDH1A1 (0.34) | KDM4EALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL11358984 | 0.71 | UPP1 (0.33) | DYRK1ATRPV4TSHR | |
| SCHEMBL5941030 | 0.71 | UPP1 (0.38) | XDHDYRK1A | |
| SCHEMBL5952373 | 0.70 | KDM4E (0.38) | KDM4EALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL1577099 | 0.70 | CYP1A2 (0.39) | KDM4EALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL14149242 | 0.70 | KDM4E (0.38) | KDM4EALDH1A1CYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440550-A1 | INDOLE AMIDE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010142801-A1 | INDOLE AMIDE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2010-12-16 | — | — | WO | disclosed |