SCHEMBL17045993

SCHEMBL17045993

CC(C)N([SiH2]c1ccccc1)c1ccccc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.36
LMNA P02545 3/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
TP53 P04637 1/20 0.36
ESR1 P03372 1/20 0.34
HTT P42858 3/20 0.33
KMT2A Q03164 2/20 0.33
MEN1 O00255 1/20 0.33
MAPT P10636 2/20 0.33
KDM4E B2RXH2 1/20 0.33
ALOX12 P18054 1/20 0.33
NPSR1 Q6W5P4 2/20 0.32
TAAR1 Q96RJ0 2/20 0.32
PTPN1 P18031 1/20 0.32
CES1 P23141 1/20 0.32
MLYCD O95822 1/20 0.31
CA12 O43570 1/20 0.31
CA2 P00918 1/20 0.31
CA9 Q16790 1/20 0.31
TRPM8 Q7Z2W7 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17053500 0.81 ALDH1A1 (0.38) ALDH1A1LMNASMN1; SMN2TP53ESR1
SCHEMBL17046156 0.79 TSHR (0.37) ALDH1A1LMNASMN1; SMN2TP53POLB
SCHEMBL17045955 0.79 ALDH1A1 (0.37) ALDH1A1LMNASMN1; SMN2TP53ESR1
SCHEMBL16405954 0.77 ALDH1A1 (0.36) ALDH1A1LMNASMN1; SMN2TP53ESR1
SCHEMBL14802979 0.77 ALDH1A1 (0.40) ALDH1A1LMNASMN1; SMN2TP53ESR1
SCHEMBL17046047 0.77 ALDH1A1 (0.36) ALDH1A1LMNASMN1; SMN2TP53ESR1
SCHEMBL17053542 0.76 ALDH1A1 (0.39) ALDH1A1LMNASMN1; SMN2TP53ESR1
SCHEMBL17053593 0.76 ALDH1A1 (0.39) ALDH1A1LMNASMN1; SMN2TP53ESR1
SCHEMBL17053624 0.74 ALDH1A1 (0.38) ALDH1A1LMNASMN1; SMN2TP53ESR1
SCHEMBL17041931 0.73 TDP1 (0.33) ALDH1A1LMNASMN1; SMN2TP53KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10294250-B2 Organoaminosilanes and methods for making same VERSUM MATERIALS US, LLC (US) 2019-05-21 US disclosed
EP-3395822-A1 ORGANOAMINOSILANES AND METHODS FOR MAKING SAME Versum Materials US, LLC (US) 2018-10-31 EP disclosed
US-9758534-B2 Organoaminosilanes and methods for making same VERSUM MATERIALS US, LLC (US) 2017-09-12 US disclosed
US-20170204120-A1 Organoaminosilanes and Methods for Making Same VERSUM MATERIALS US, LLC (US) 2017-07-20 US disclosed
US-20170204120-A1 Organoaminosilanes and Methods for Making Same VERSUM MATERIALS US, LLC (US) 2017-07-20 US disclosed
US-20160168169-A1 ORGANOAMINOSILANES AND METHODS FOR MAKING SAME AIR PRODUCTS AND CHEMICALS, INC. (US) 2016-06-16 US disclosed
US-20160168169-A1 ORGANOAMINOSILANES AND METHODS FOR MAKING SAME AIR PRODUCTS AND CHEMICALS, INC. (US) 2016-06-16 US disclosed
US-9233990-B2 Organoaminosilanes and methods for making same AIR PRODUCTS AND CHEMICALS, INC. (US) 2016-01-12 US disclosed
US-9233990-B2 Organoaminosilanes and methods for making same AIR PRODUCTS AND CHEMICALS, INC. (US) 2016-01-12 US disclosed
US-20150246937-A1 ORGANOAMINOSILANES AND METHODS FOR MAKING SAME AIR PRODUCTS AND CHEMICALS, INC. (US) 2015-09-03 US disclosed
US-20150246937-A1 ORGANOAMINOSILANES AND METHODS FOR MAKING SAME AIR PRODUCTS AND CHEMICALS, INC. (US) 2015-09-03 US disclosed
US-20150246937-A1 ORGANOAMINOSILANES AND METHODS FOR MAKING SAME AIR PRODUCTS AND CHEMICALS, INC. (US) 2015-09-03 US disclosed
EP-2913334-A1 Organoaminosilanes and methods for making same AIR PRODUCTS AND CHEMICALS, INC. (US) 2015-09-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150246937-A1 ORGANOAMINOSILANES AND METHODS FOR MAKING SAME DDAH1, IDUA, DDT ALDH1A1 418/4885LMNA 1902/4885SMN1; SMN2 2844/4885
US-20170204120-A1 Organoaminosilanes and Methods for Making Same DDAH1, IDUA, DDT ALDH1A1 418/4885LMNA 1902/4885SMN1; SMN2 2844/4885
US-10294250-B2 Organoaminosilanes and methods for making same DDAH1, IDUA, DDT ALDH1A1 418/4885LMNA 1902/4885SMN1; SMN2 2844/4885
US-20160168169-A1 ORGANOAMINOSILANES AND METHODS FOR MAKING SAME DDAH1, IDUA, DDT ALDH1A1 418/4885LMNA 1902/4885SMN1; SMN2 2844/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.