Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29905605 | 0.75 | POLB (0.93) | POLBKMT2ATSHRKDM4EALDH1A1 | |
| SCHEMBL5280013 | 0.75 | POLB (0.93) | POLBKMT2ATSHRKDM4EALDH1A1 | |
| SCHEMBL1546827 | 0.72 | POLB (0.87) | POLBKMT2ATSHRKDM4EALDH1A1 | |
| SCHEMBL21361650 | 0.68 | KDM4E (0.60) | POLBKMT2ATSHRKDM4EALDH1A1 | |
| SCHEMBL5314300 | 0.67 | KMT2A (0.81) | POLBKMT2ATSHRKDM4EALDH1A1 | |
| SCHEMBL30392490 | 0.63 | TSHR (0.95) | POLBKMT2ATSHRKDM4EALDH1A1 | |
| SCHEMBL9028142 | 0.63 | POLB (0.67) | POLBKMT2ATSHRKDM4EALDH1A1 | |
| SCHEMBL3176249 | 0.63 | KDM4E (1.00) | POLBKMT2ATSHRKDM4EALDH1A1 | |
| SCHEMBL6962582 | 0.63 | POLB (0.67) | POLBKMT2ATSHRKDM4EALDH1A1 | |
| SCHEMBL417152 | 0.62 | CA1 (0.58) | POLBKMT2ATSHRKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015130445-A1 | QUINOLINE DERIVATIVES USEFUL AS CB-1 INVERSE AGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2015-09-03 | — | — | WO | disclosed |
| WO-2015130444-A1 | QUINOLINE DERIVATIVES USEFUL AS CB-1 INVERSE AGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2015-09-03 | — | — | WO | disclosed |