Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.45 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.45 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 4/20 | 0.44 |
| ▸ | DRD3 | P35462 | 4/20 | 0.44 |
| ▸ | GBA1 | P04062 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2271581 | 1.00 | MAPT (0.65) | MAPTPDK1PDK2PDK3PDK4 | |
| SCHEMBL3601179 | 1.00 | MAPT (0.65) | MAPTPDK1PDK2PDK3PDK4 | |
| SCHEMBL3597729 | 1.00 | MAPT (0.65) | MAPTPDK1PDK2PDK3PDK4 | |
| SCHEMBL3601182 | 1.00 | MAPT (0.65) | MAPTPDK1PDK2PDK3PDK4 | |
| SCHEMBL3597725 | 1.00 | MAPT (0.65) | MAPTPDK1PDK2PDK3PDK4 | |
| SCHEMBL28053573 | 0.84 | SIGMAR1 (0.54) | MAPTGBA1SIGMAR1 | |
| SCHEMBL22873347 | 0.84 | MAPT (0.54) | MAPTDRD2DRD3GBA1SIGMAR1 | |
| SCHEMBL17453685 | 0.84 | MAPT (0.60) | MAPTPDK1PDK2PDK3PDK4 | |
| SCHEMBL17453682 | 0.84 | MAPT (0.60) | MAPTPDK1PDK2PDK3PDK4 | |
| SCHEMBL19102147 | 0.84 | MAPT (0.60) | MAPTPDK1PDK2PDK3PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015128334-A9 | 3H-THIENO[3,4]PYRIMIDIN-4-ONEAND PYRROLOPYRIMID-4-ONE AS GRAM-POSITIVE ANTIBACTERIAL AGENTS | LABORATOIRE BIODIM (FR) | 2015-10-15 | — | — | WO | disclosed |
| WO-2015128334-A1 | 3H-THIENO[3,4]PYRIMIDIN-4-ONEAND PYRROLOPYRIMID-4-ONE AS GRAM-POSITIVE ANTIBACTERIAL AGENTS | LABORATOIRE BIODIM (FR) | 2015-09-03 | — | — | WO | disclosed |