Tyrphostin 47

Tyrphostin 47

SCHEMBL1704818

N#CC(=Cc1ccc(O)c(O)c1)C(N)=S

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 10/20 1.00
ALDH1A1 P00352 9/20 1.00
MAPT P10636 8/20 1.00
KDM4E B2RXH2 7/20 1.00
HPGD P15428 7/20 1.00
KMT2A Q03164 7/20 1.00
TDP1 Q9NUW8 7/20 1.00
MEN1 O00255 6/20 1.00
BLM P54132 5/20 1.00
CYP1A2 P05177 5/20 1.00
HSD17B10 Q99714 5/20 1.00
ERBB2 P04626 5/20 1.00
DNM1 Q05193 5/20 1.00
RECQL P46063 4/20 1.00
TP53 P04637 4/20 1.00
PMP22 Q01453 4/20 1.00
CYP3A4 P08684 4/20 1.00
ALOX15 P16050 4/20 1.00
HIF1A Q16665 4/20 1.00
ALOX12 P18054 3/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tyrphostin 47 SCHEMBL5802738 1.00 EGFR (1.00) EGFRALDH1A1MAPTKDM4EHPGD
Tyrphostin 47 SCHEMBL6055056 1.00 EGFR (1.00) EGFRALDH1A1MAPTKDM4EHPGD
Tyrphostin 47 SCHEMBL29378969 1.00 EGFR (1.00) EGFRALDH1A1MAPTKDM4EHPGD
Tyrphostin 47 SCHEMBL5802735 1.00 EGFR (1.00) EGFRALDH1A1MAPTKDM4EHPGD
Tyrphostin 47 SCHEMBL29422960 1.00 EGFR (1.00) EGFRALDH1A1MAPTKDM4EHPGD
Tyrphostin 47 SCHEMBL5800282 1.00 EGFR (1.00) EGFRALDH1A1MAPTKDM4EHPGD
SCHEMBL13060220 0.86 EGFR (0.77) EGFRALDH1A1MAPTKDM4EHPGD
SCHEMBL6285299 0.83 EGFR (1.00) EGFRALDH1A1MAPTKDM4EHPGD
SCHEMBL1705642 0.83 EGFR (1.00) EGFRALDH1A1MAPTKDM4EHPGD
SCHEMBL7908162 0.83 EGFR (0.71) EGFRALDH1A1MAPTKDM4EHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3841097-B1 2,6-BIS(((1H-BENZO[D]IMIDAZOL-2-YL)THIO)METHYL)PYRIDINE AND N2,N6-DIBENZYLPYRIDINE-2,6-DICARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS PHOSPHOINOSITIDE 3-KINASE (PI3K) INHIBITORS FOR TREATING CANCER BIOMEDICAL RES FOUNDATION OF THE ACADEMY OF ATHENS BRFAA (GR) 2026-05-20 EP claimed
EP-3319965-B1 NOVEL COMPOUNDS FOR USE IN TREATING OR PREVENTING CANCEROUS DISEASES BIOMEDICAL RES FOUNDATION OF THE ACADEMY OF ATHENS (GR) 2022-05-04 EP claimed
CN-113272294-A 2, 6-bis (((1H-benzo [ D ] imidazol-2-yl) thio) methyl) pyridine and N2, N6-dibenzylpyridine-2, 6-dicarboxamide derivatives and related compounds as phosphoinositide 3-kinase (PI3K) inhibitors for the treatment of cancer 雅典学院生物医学研究基金会 2021-08-17 CN claimed
US-20210246120-A1 METHOD OF PREPARATION AND USE OF PHOSPHOINOSITIDE 3-KINASE INHIBITORS IN TREATING CANCER FOUNDATION FOR RESEARCH AND TECHNOLOGY HELLAS (FORTH) (GR) 2021-08-12 US claimed
EP-3841097-A1 2,6-BIS(((1H-BENZO[D]IMIDAZOL-2-YL)THIO)METHYL)PYRIDINE AND N2,N6-DIBENZYLPYRIDINE-2,6-DICARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS PHOSPHOINOSITIDE 3-KINASE (PI3K) INHIBITORS FOR TREATING CANCER Biomedical Research Foundation of the Academy of Athens (GR) 2021-06-30 EP claimed
WO-2020039097-A1 2,6-BIS(((1H-BENZO[D]IMIDAZOL-2-YL)THIO)METHYL)PYRIDINE AND N2,N6-DIBENZYLPYRIDINE-2,6-DICARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS PHOSPHOINOSITIDE 3-KINASE (PI3K) INHIBITORS FOR TREATING CANCER BIOMEDICAL RESEARCH FOUNDATION OF THE ACADEMY OF ATHENS (BRFAA) (GR) 2020-02-27 WO claimed
US-10287294-B2 Compounds for use in treating or preventing cancerous diseases BIOMEDICAL RESEARCH FOUNDATION OF THE ACADEMY OF ATHENS (GR) 2019-05-14 US claimed
US-20180208597-A1 NOVEL COMPOUNDS FOR USE IN TREATING OR PREVENTING CANCEROUS DISEASES BIOMEDICAL RESEARCH FOUNDATION OF THE ACADEMY OF ATHENS (GR) 2018-07-26 US claimed
EP-3319965-A1 NOVEL COMPOUNDS FOR USE IN TREATING OR PREVENTING CANCEROUS DISEASES Biomedical Research Foundation of the Academy of Athens (GR) 2018-05-16 EP claimed
WO-2017005919-A1 NOVEL COMPOUNDS FOR USE IN TREATING OR PREVENTING CANCEROUS DISEASES BIOMEDICAL RESEARCH FOUNDATION OF THE ACADEMY OF ATHENS (GR) 2017-01-12 WO claimed
EP-1156775-B1 REDUCTION OF HAIR GROWTH GILLETTE CO (US) 2006-05-17 EP claimed
EP-1482983-A2 NON-MYELOABLATIVE TOLEROGENIC TREATMENT WITH TYRPHOSTINS YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) 2004-12-08 EP claimed
US-20040197335-A1 Non-myeloablative tolerogenic treatment with tyrphostins HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. (IL) 2004-10-07 US claimed
WO-2003065971-A9 NON-MYELOABLATIVE TOLEROGENIC TREATMENT WITH TYRPHOSTINS YISSUM RES DEV CO (IL) 2003-11-20 WO claimed
WO-2003065971-A2 NON-MYELOABLATIVE TOLEROGENIC TREATMENT WITH TYRPHOSTINS YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) 2003-08-14 WO claimed
EP-1156775-A1 REDUCTION OF HAIR GROWTH THE GILLETTE COMPANY (US) 2001-11-28 EP claimed
US-6121269-A TOPICALLY APPLYING A PROTEIN-TYROSINE KINASE INHIBITOR TO SKIN TO REDUCE ANDROGEN-STIMULATED HAIR GROWTH WITHOUT SIDE EFFECTS GILLETTE COMPANY, THE, A DELAWARE CORPORATION 2000-09-19 US claimed
WO-2000050002-A1 REDUCTION OF HAIR GROWTH THE GILLETTE COMPANY (US) 2000-08-31 WO claimed
EP-0614661-A2 Benzylidene- and cinnamylidine-malononitrile derivatives for the inhibition of proliferative processes in mammalian cells YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) 1994-09-14 EP claimed
EP-0322738-A2 Benzylidene-malononitrile derivatives for the inhibition of proliferative processes in mammalian cells YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) 1989-07-05 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210246120-A1 METHOD OF PREPARATION AND USE OF PHOSPHOINOSITIDE 3-KINASE INHIBITORS IN TREATING CANCER PIK3R3, PIK3CA, PIK3C2A EGFR 675/4885ALDH1A1 3224/4885MAPT 4764/4885
US-20180208597-A1 NOVEL COMPOUNDS FOR USE IN TREATING OR PREVENTING CANCEROUS DISEASES BRCA1, VHL, TSG101 EGFR 1141/4885ALDH1A1 71/4885MAPT 2960/4885
US-10287294-B2 Compounds for use in treating or preventing cancerous diseases BRCA1, VHL, CYP27A1 EGFR 1052/4885ALDH1A1 48/4885MAPT 2584/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.