Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 13/20 | 0.50 |
| ▸ | SYK | P43405 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.44 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902920 | 0.90 | SYK (0.50) | KARS1SYKALDH1A1LMNAMAPT | |
| SCHEMBL901842 | 0.88 | KARS1 (0.54) | KARS1 | |
| SCHEMBL901840 | 0.88 | KARS1 (0.54) | KARS1 | |
| SCHEMBL1705146 | 0.88 | SYK (0.57) | KARS1SYKALDH1A1LMNAMAPT | |
| SCHEMBL901333 | 0.87 | KARS1 (0.65) | KARS1SYKGPR119TBK1LRRK2 | |
| SCHEMBL1704643 | 0.87 | MAPT (0.47) | KARS1SYKALDH1A1LMNAMAPT | |
| SCHEMBL1704453 | 0.86 | KARS1 (0.52) | KARS1SYKGPR119TBK1LRRK2 | |
| SCHEMBL1704732 | 0.86 | KARS1 (0.52) | KARS1SYKGPR119TBK1LRRK2 | |
| SCHEMBL902995 | 0.86 | KARS1 (0.67) | KARS1SYKGPR119TBK1LRRK2 | |
| SCHEMBL901508 | 0.86 | KARS1 (0.56) | KARS1SYKGPR119TBK1LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |