Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 2/20 | 0.42 |
| ▸ | SYK | P43405 | 2/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | GBA1 | P04062 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | WNT3A | P56704 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901813 | 0.88 | ALDH1A1 (0.40) | MAPTALDH1A1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL1704429 | 0.87 | KARS1 (0.46) | MAPTSYKKITBRAFGPR119 | |
| SCHEMBL1704894 | 0.87 | KARS1 (0.50) | MAPTALDH1A1LMNASYKGPR119 | |
| SCHEMBL10269155 | 0.78 | WNT3A (0.43) | SYKJAK1WNT3ACCNT1CDK9 | |
| SCHEMBL902983 | 0.77 | KARS1 (0.64) | SYKKITGPR119JAK2GBA1 | |
| SCHEMBL902920 | 0.76 | SYK (0.50) | MAPTALDH1A1LMNASYKWNT3A | |
| SCHEMBL20564686 | 0.76 | MAPT (0.68) | MAPTALDH1A1LMNAMETGPR119 | |
| SCHEMBL1705146 | 0.74 | SYK (0.57) | MAPTALDH1A1LMNASYKKARS1 | |
| SCHEMBL1705093 | 0.73 | KARS1 (0.53) | SYKGPR119KARS1 | |
| SCHEMBL901842 | 0.73 | KARS1 (0.54) | KARS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |