Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 13/20 | 0.73 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.50 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902572 | 0.97 | KARS1 (0.69) | KARS1GPR119SYKPTPN2PTPN1 | |
| SCHEMBL1705200 | 0.97 | KARS1 (0.78) | KARS1GPR119SYKPTPN2PTPN1 | |
| SCHEMBL902991 | 0.94 | KARS1 (0.67) | KARS1GPR119SYKTP53KDM4E | |
| SCHEMBL1705215 | 0.92 | KARS1 (0.62) | KARS1GPR119SYK | |
| SCHEMBL1704257 | 0.90 | KARS1 (0.61) | KARS1GPR119SYK | |
| SCHEMBL902995 | 0.89 | KARS1 (0.67) | KARS1GPR119SYK | |
| SCHEMBL902904 | 0.88 | KARS1 (0.57) | KARS1GPR119SYK | |
| SCHEMBL902022 | 0.88 | KARS1 (0.57) | KARS1GPR119SYK | |
| SCHEMBL1704600 | 0.87 | KARS1 (0.73) | KARS1GPR119SYK | |
| SCHEMBL1704251 | 0.87 | KARS1 (0.73) | KARS1GPR119SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |