SCHEMBL17050141

SCHEMBL17050141

Cc1ccc(-c2ccc(-c3cc(F)c(OC(F)(F)C(F)F)c(F)c3)c(F)c2)cc1

nearest known ligand 0.36

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
PDK2 Q15119 1/20 0.36
PDE3B Q13370 1/20 0.34
PDE3A Q14432 1/20 0.34
ABL1 P00519 1/20 0.34
BCR P11274 1/20 0.34
SCN9A Q15858 1/20 0.34
ALKBH3 Q96Q83 2/20 0.34
ALOX5AP P20292 3/20 0.34
FEN1 P39748 3/20 0.34
PTGS2 P35354 1/20 0.33
RPS6KA3 P51812 1/20 0.33
AR P10275 1/20 0.33
CYP11B1 P15538 2/20 0.33
CYP11B2 P19099 2/20 0.33
AKR1C3 P42330 3/20 0.32
AKR1C2 P52895 3/20 0.32
APP P05067 1/20 0.32
CYP2C19 P33261 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13265423 0.87 ALOX5AP (0.39) PDK2PDE3BPDE3AALKBH3ALOX5AP
SCHEMBL4567627 0.87 ALOX5AP (0.39) PDK2PDE3BPDE3AALKBH3ALOX5AP
SCHEMBL17050148 0.83 RARB (0.37) PDK2ALOX5APFEN1AKR1C3AKR1C2
SCHEMBL17050142 0.82 RARB (0.36) PDK2ALOX5APFEN1AKR1C3AKR1C2
SCHEMBL13480374 0.81 PDE3B (0.36) PDK2PDE3BPDE3ASCN9AALKBH3
SCHEMBL20118151 0.77 ALOX5AP (0.37) PDK2PDE3BPDE3AALKBH3ALOX5AP
SCHEMBL170435 0.76 PDE3B (0.49) PDK2PDE3BPDE3AALOX5APFEN1
SCHEMBL17050129 0.76 PDK2 (0.33) PDK2AKR1C3AKR1C2
SCHEMBL18559871 0.76 PTGS2 (0.38) SCN9AALOX5APFEN1PTGS2CYP11B1
SCHEMBL14234532 0.75 AR (0.41) PDK2PDE3BPDE3APTGS2RPS6KA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015129540-A1 LIQUID CRYSTAL COMPOUND HAVING 1,1,3,3-TETRAFLUOROALLYLOXY GROUP, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY ELEMENT JNC株式会社 2015-09-03 WO disclosed