SCHEMBL20118151

SCHEMBL20118151

Cc1ccc(-c2ccc(-c3cc(F)c(C(F)(F)Oc4cc(F)c(OC(F)(F)F)c(F)c4)c(F)c3)c(F)c2)cc1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5AP P20292 2/20 0.37
FEN1 P39748 2/20 0.37
GPR3 P46089 1/20 0.34
GRM2 Q14416 1/20 0.33
PDK2 Q15119 1/20 0.32
FFAR4 Q5NUL3 2/20 0.32
FFAR1 O14842 1/20 0.32
ERN1 O75460 1/20 0.32
PDE3B Q13370 1/20 0.31
PDE3A Q14432 1/20 0.31
AKR1C3 P42330 2/20 0.31
AKR1C2 P52895 2/20 0.31
CYP11B1 P15538 1/20 0.31
CYP11B2 P19099 1/20 0.31
ALKBH3 Q96Q83 2/20 0.30
CYP2C19 P33261 2/20 0.30
APP P05067 1/20 0.30
PTGS2 P35354 1/20 0.30
CYP1A2 P05177 1/20 0.30
MAPT P10636 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10018743 0.91 CYP11B1 (0.32) ALOX5APFEN1GPR3FFAR4FFAR1
SCHEMBL18324922 0.89 ALOX5AP (0.37) ALOX5APFEN1GRM2FFAR4FFAR1
SCHEMBL21063847 0.89 GPR3 (0.43) ALOX5APFEN1GPR3GRM2FFAR4
SCHEMBL2741563 0.89 ALOX5AP (0.34) ALOX5APFEN1GPR3GRM2PDK2
SCHEMBL15933152 0.89 ALOX5AP (0.34) ALOX5APFEN1GPR3GRM2PDK2
SCHEMBL10259805 0.89 ALOX5AP (0.34) ALOX5APFEN1PDK2ERN1PDE3B
SCHEMBL19850725 0.89 ALOX5AP (0.42) ALOX5APFEN1GPR3GRM2PDK2
SCHEMBL13447418 0.89 ALOX5AP (0.34) ALOX5APFEN1GPR3GRM2PDK2
SCHEMBL4567627 0.88 ALOX5AP (0.39) ALOX5APFEN1GPR3GRM2PDK2
SCHEMBL13265423 0.88 ALOX5AP (0.39) ALOX5APFEN1GPR3GRM2PDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180119011-A1 LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE THEREOF JIANGSU HECHENG DISPLAY TECHNOLOGY CO., LTD. (CN) 2018-05-03 US disclosed