Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 11/20 | 0.41 |
| ▸ | KARS1 | Q15046 | 4/20 | 0.41 |
| ▸ | MAP3K12 | Q12852 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704569 | 0.88 | SYK (0.46) | SYKKARS1MAP3K12 | |
| SCHEMBL1704571 | 0.88 | SYK (0.46) | SYKKARS1MAP3K12 | |
| SCHEMBL901796 | 0.87 | KARS1 (0.45) | SYKKARS1MAP3K12 | |
| SCHEMBL1705559 | 0.80 | KARS1 (0.51) | SYKKARS1MAP3K12 | |
| SCHEMBL12469310 | 0.76 | KARS1 (0.56) | SYKKARS1MAP3K12 | |
| SCHEMBL1704085 | 0.75 | SYK (0.49) | SYKKARS1 | |
| SCHEMBL902920 | 0.73 | SYK (0.50) | SYKKARS1MAPT | |
| SCHEMBL901369 | 0.72 | KARS1 (0.45) | SYKKARS1MEN1KMT2A | |
| SCHEMBL901370 | 0.72 | KARS1 (0.45) | SYKKARS1MEN1KMT2A | |
| SCHEMBL1704871 | 0.70 | KARS1 (0.44) | SYKKARS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |