Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 13/20 | 0.56 |
| ▸ | MAP3K12 | Q12852 | 3/20 | 0.39 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 3/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901796 | 0.88 | KARS1 (0.45) | KARS1MAP3K12SYK | |
| SCHEMBL1704085 | 0.86 | SYK (0.49) | KARS1SYK | |
| SCHEMBL901253 | 0.84 | KARS1 (0.65) | KARS1TYK2 | |
| SCHEMBL902062 | 0.82 | KARS1 (0.57) | KARS1TYK2 | |
| SCHEMBL901409 | 0.82 | KARS1 (0.41) | KARS1MAP3K12MAP3K13TYK2 | |
| SCHEMBL901738 | 0.81 | KARS1 (0.58) | KARS1SYK | |
| SCHEMBL901752 | 0.79 | KARS1 (0.73) | KARS1 | |
| SCHEMBL902168 | 0.76 | SYK (0.49) | SYK | |
| SCHEMBL1704543 | 0.76 | SYK (0.49) | SYK | |
| SCHEMBL1705079 | 0.76 | SYK (0.41) | KARS1MAP3K12SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |