Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.63 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.63 |
| ▸ | KCNK3 | O14649 | 12/20 | 0.59 |
| ▸ | KCNK9 | Q9NPC2 | 10/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1690508 | 0.88 | MEN1 (0.68) | MEN1KMT2ARXFP1KCNK3KCNK9 | |
| SCHEMBL1696311 | 0.84 | MEN1 (0.70) | MEN1KMT2ARXFP1KCNK3KCNK9 | |
| SCHEMBL15676738 | 0.84 | MEN1 (0.74) | MEN1KMT2ARXFP1KCNK3KCNK9 | |
| SCHEMBL17052993 | 0.80 | MEN1 (0.72) | MEN1KMT2ARXFP1KCNK3KCNK9 | |
| SCHEMBL4253897 | 0.79 | KCNK3 (0.93) | MEN1KMT2ARXFP1KCNK3KCNK9 | |
| SCHEMBL18718041 | 0.77 | NPC1 (0.56) | MEN1KMT2ARAB9ALMNATP53 | |
| SCHEMBL21377635 | 0.77 | KCNK3 (0.77) | MEN1KMT2ARXFP1KCNK3KCNK9 | |
| SCHEMBL1690509 | 0.76 | NPC1 (0.57) | MEN1KMT2ARXFP1KCNK3KCNK9 | |
| SCHEMBL20064059 | 0.76 | KCNK3 (0.77) | MEN1KMT2ARXFP1KCNK3KCNK9 | |
| SCHEMBL18717450 | 0.76 | LOXL2 (0.59) | MEN1KMT2ARAB9AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9617224-B2 | Five-membered heterocycles useful as serine protease inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-04-11 | — | — | US | disclosed |