Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 13/20 | 0.57 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704239 | 0.96 | KARS1 (0.56) | KARS1DYRK1ATBK1 | |
| SCHEMBL901895 | 0.92 | KARS1 (0.52) | KARS1TBK1 | |
| SCHEMBL901882 | 0.92 | KARS1 (0.48) | KARS1DYRK1ATBK1 | |
| SCHEMBL1704636 | 0.88 | KARS1 (0.52) | KARS1TBK1 | |
| SCHEMBL1704312 | 0.87 | KARS1 (0.48) | KARS1TBK1 | |
| SCHEMBL1704395 | 0.87 | KARS1 (0.53) | KARS1TBK1 | |
| SCHEMBL902563 | 0.86 | KARS1 (0.65) | KARS1DYRK1ARAF1BRAFGSK3B | |
| SCHEMBL901789 | 0.84 | KARS1 (0.75) | KARS1 | |
| SCHEMBL902673 | 0.83 | KARS1 (0.65) | KARS1DYRK1ATBK1 | |
| SCHEMBL1704582 | 0.82 | KARS1 (0.53) | KARS1TBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |