Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 13/20 | 0.52 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.33 |
| ▸ | WNT3A | P56704 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704636 | 0.96 | KARS1 (0.52) | KARS1P2RY12ACHETBK1WNT3A | |
| SCHEMBL1705340 | 0.92 | KARS1 (0.57) | KARS1TBK1 | |
| SCHEMBL1704395 | 0.90 | KARS1 (0.53) | KARS1ACHETBK1WNT3A | |
| SCHEMBL901882 | 0.90 | KARS1 (0.48) | KARS1ACHETBK1 | |
| SCHEMBL1704239 | 0.88 | KARS1 (0.56) | KARS1ACHETBK1WNT3A | |
| SCHEMBL1704582 | 0.85 | KARS1 (0.53) | KARS1ACHETBK1WNT3A | |
| SCHEMBL1704312 | 0.85 | KARS1 (0.48) | KARS1ACHETBK1 | |
| SCHEMBL901878 | 0.83 | KARS1 (0.69) | KARS1 | |
| SCHEMBL901431 | 0.83 | KARS1 (0.60) | KARS1 | |
| SCHEMBL1704481 | 0.83 | KARS1 (0.55) | KARS1ACHETBK1WNT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |