Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 14/20 | 0.57 |
| ▸ | PIK3CD | O00329 | 11/20 | 0.57 |
| ▸ | MTOR | P42345 | 9/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
| ▸ | RAF1 | P04049 | 3/20 | 0.41 |
| ▸ | BRAF | P15056 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1705852 | 0.89 | PIK3CA (0.50) | PIK3CAPIK3CDMTORPIK3CBPIK3CG | |
| SCHEMBL1706192 | 0.83 | PIK3CA (0.74) | PIK3CAPIK3CDMTOR | |
| SCHEMBL737932 | 0.81 | PIK3CA (0.81) | PIK3CAPIK3CDMTORPIK3CBPIK3CG | |
| SCHEMBL1706152 | 0.80 | PIK3CA (0.61) | PIK3CAPIK3CDMTOR | |
| SCHEMBL1705895 | 0.80 | PIK3CA (0.68) | PIK3CAPIK3CDMTOR | |
| SCHEMBL1705779 | 0.79 | PIK3CA (0.63) | PIK3CAPIK3CDMTORPIK3CBPIK3CG | |
| SCHEMBL737810 | 0.77 | PIK3CA (0.55) | PIK3CAPIK3CDMTOR | |
| SCHEMBL3604473 | 0.75 | PIK3CA (0.75) | PIK3CAPIK3CDMTORPIK3CBPIK3CG | |
| SCHEMBL3608924 | 0.75 | PIK3CA (0.85) | PIK3CAPIK3CDMTORPIK3CBPIK3CG | |
| SCHEMBL3597508 | 0.75 | PIK3CA (0.76) | PIK3CAPIK3CDMTORPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2176238-B1 | MORPHOLINO PYRIMIDINE DERIVATIVES USED IN DISEASES LINKED TO MTOR KINASE AND/OR PI3K | ASTRAZENECA AB (SE) | 2012-04-18 | — | — | EP | claimed |