Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGA4 | P13612 | 3/20 | 0.62 |
| ▸ | ITGB7 | P26010 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 6/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.60 |
| ▸ | BLM | P54132 | 1/20 | 0.60 |
| ▸ | KDM1A | O60341 | 1/20 | 0.59 |
| ▸ | MAOA | P21397 | 1/20 | 0.59 |
| ▸ | GRK5 | P34947 | 1/20 | 0.57 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.57 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.57 |
| ▸ | EP300 | Q09472 | 1/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | IDH1 | O75874 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21654415 | 1.00 | ITGA4 (0.62) | ITGA4ITGB7MEN1KMT2APOLB | |
| SCHEMBL12932191 | 1.00 | ITGA4 (0.62) | ITGA4ITGB7MEN1KMT2APOLB | |
| SCHEMBL12218472 | 0.84 | MAPT (0.61) | ITGA4ITGB7MEN1KMT2APOLB | |
| SCHEMBL13479533 | 0.84 | PSMB5 (0.74) | ITGA4ITGB7MEN1KMT2APOLB | |
| SCHEMBL22523873 | 0.82 | SIRT1 (0.74) | ITGA4ITGB7MEN1KMT2APOLB | |
| SCHEMBL13479513 | 0.76 | MEN1 (0.60) | ITGA4ITGB7MEN1KMT2APOLB | |
| SCHEMBL15702610 | 0.76 | KMT2A (0.67) | MEN1KMT2APOLBGAAUSP2 | |
| SCHEMBL14444644 | 0.75 | MEN1 (1.00) | ITGA4ITGB7MEN1KMT2APOLB | |
| SCHEMBL30457527 | 0.75 | MEN1 (1.00) | ITGA4ITGB7MEN1KMT2APOLB | |
| SCHEMBL13707124 | 0.75 | NR1H4 (0.62) | MEN1KMT2APOLBGAAEP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222326-B2 | INHIBITORS OF MALT1 PROTEOLYTIC ACTIVITY AND USES THEREOF | VIB VZW (BE) | 2015-02-25 | — | — | EP | disclosed |
| EP-2222326-B1 | Inhibitors of MALT1-proteolytic activity and uses thereof | VIB VZW (BE) | 2012-04-18 | — | — | EP | disclosed |