Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.36 |
| ▸ | VNN1 | O95497 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20307157 | 0.90 | KMT2A (0.57) | KMT2AHTTALDH1A1CYP2C9CYP1A2 | |
| SCHEMBL24664430 | 0.82 | KMT2A (0.59) | KMT2AHTTCYP2D6DPP4RORC | |
| SCHEMBL17035434 | 0.81 | POLB (0.48) | ALDH1A1CYP2C9CYP1A2CYP2D6HDAC3 | |
| SCHEMBL17032813 | 0.79 | CYP1A2 (0.57) | ALDH1A1CYP2C9CYP1A2CYP2D6TSHR | |
| SCHEMBL14617960 | 0.77 | ALDH1A1 (0.44) | KMT2AALDH1A1DPP4DPP7EPHX2 | |
| SCHEMBL17034780 | 0.77 | LMNA (0.42) | ALDH1A1CYP2C9CYP1A2CYP2D6HDAC3 | |
| SCHEMBL965286 | 0.76 | KMT2A (0.82) | KMT2AHTTALDH1A1EPHX2LMNA | |
| SCHEMBL19741751 | 0.76 | — | — | |
| SCHEMBL17176083 | 0.75 | KMT2A (0.61) | KMT2AHTTALDH1A1CYP2D6EPHX2 | |
| SCHEMBL17039080 | 0.75 | TSHR (0.43) | HTTALDH1A1CYP2C9CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015130795-A1 | AMIDE COMPOUNDS FOR TREATMENT OF COMPLEMENT MEDIATED DISORDERS | ACHILLION PHARMACEUTICALS, INC. (US) | 2015-09-03 | — | — | WO | disclosed |