Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCTPP1 | Q9H773 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.33 |
| ▸ | HPGDS | O60760 | 2/20 | 0.33 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | CKS1B | P61024 | 1/20 | 0.33 |
| ▸ | SKP1 | P63208 | 1/20 | 0.33 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11944507 | 0.85 | ALDH1A1 (0.37) | DCTPP1ALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL11944533 | 0.84 | ALDH1A1 (0.47) | DCTPP1ALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL17058094 | 0.84 | ALDH1A1 (0.36) | ALDH1A1SMN1; SMN2LMNAPOLBKMT2A | |
| SCHEMBL17058115 | 0.83 | SMN1; SMN2 (0.36) | DCTPP1ALDH1A1SMN1; SMN2KDM4EPKM | |
| SCHEMBL17057805 | 0.81 | CA12 (0.37) | DCTPP1ALDH1A1SMN1; SMN2KDM4ELMNA | |
| SCHEMBL11944387 | 0.80 | POLB (0.41) | DCTPP1ALDH1A1SMN1; SMN2KDM4EPKM | |
| SCHEMBL17058068 | 0.78 | HTR1A (0.39) | ALDH1A1SMN1; SMN2KDM4EPKMLMNA | |
| SCHEMBL11944857 | 0.77 | POLB (0.41) | DCTPP1ALDH1A1SMN1; SMN2KDM4EPKM | |
| SCHEMBL17058376 | 0.76 | SMN1; SMN2 (0.36) | DCTPP1ALDH1A1SMN1; SMN2KDM4EPKM | |
| SCHEMBL17057946 | 0.75 | SLC2A1 (0.38) | DCTPP1ALDH1A1SMN1; SMN2KDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137179-B1 | PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | MERCK SHARP & DOHME (US) | 2015-09-02 | — | — | EP | disclosed |