Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.34 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.34 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NPBWR1 | P48145 | 4/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NPY2R | P49146 | 1/20 | 0.30 |
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.30 |
| ▸ | THRA | P10827 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17058065 | 0.94 | SLC2A1 (0.31) | SLC2A1SLC2A3MCHR1DCTPP1 | |
| SCHEMBL11944190 | 0.85 | NPSR1 (0.40) | NPSR1SLC2A1SLC2A3POLBCYP3A4 | |
| SCHEMBL17058398 | 0.83 | SLC2A1 (0.33) | NPSR1SLC2A1SLC2A3POLBCYP3A4 | |
| SCHEMBL17058243 | 0.81 | ALDH1A1 (0.36) | NPSR1SLC2A1SLC2A3POLBCYP3A4 | |
| SCHEMBL17057784 | 0.81 | ALDH1A1 (0.35) | NPSR1SLC2A1SLC2A3POLBCYP3A4 | |
| SCHEMBL17058397 | 0.81 | ALDH1A1 (0.35) | NPSR1SLC2A1SLC2A3POLBCYP3A4 | |
| SCHEMBL11944315 | 0.79 | MAPT (0.44) | NPSR1POLBCYP3A4CYP2C19PPARG | |
| SCHEMBL11944133 | 0.79 | NPSR1 (0.37) | NPSR1SLC2A1SLC2A3POLBCYP3A4 | |
| SCHEMBL17058036 | 0.78 | SLC2A1 (0.31) | SLC2A1SLC2A3NPBWR1MCHR1 | |
| SCHEMBL11944291 | 0.78 | MAPT (0.38) | NPSR1SLC2A1SLC2A3POLBCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137179-B1 | PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | MERCK SHARP & DOHME (US) | 2015-09-02 | — | — | EP | disclosed |