Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 6/20 | 0.37 |
| ▸ | NPBWR1 | P48145 | 8/20 | 0.32 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.32 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.30 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.30 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.30 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11944480 | 0.86 | MAPT (0.36) | MCHR1NPBWR1SLC2A1SLC2A3ALDH1A1 | |
| SCHEMBL17058270 | 0.85 | CYP1A2 (0.35) | MCHR1NPBWR1SLC2A1SLC2A3ALDH1A1 | |
| SCHEMBL17057870 | 0.85 | MCHR1 (0.36) | MCHR1NPBWR1SLC2A1SLC2A3ALDH1A1 | |
| SCHEMBL17058373 | 0.82 | MAPT (0.46) | MCHR1NPBWR1ALDH1A1NPSR1DCTPP1 | |
| SCHEMBL14899767 | 0.81 | MAPT (0.34) | MCHR1SLC2A1SLC2A3ALDH1A1NPSR1 | |
| SCHEMBL11944357 | 0.80 | MAPT (0.45) | ALDH1A1NPSR1DCTPP1CYP2C19POLB | |
| SCHEMBL17058044 | 0.79 | MCHR1 (0.39) | MCHR1NPBWR1SLC2A1SLC2A3ALDH1A1 | |
| SCHEMBL17058111 | 0.79 | ALDH1A1 (0.34) | MCHR1NPBWR1SLC2A1SLC2A3ALDH1A1 | |
| SCHEMBL17058290 | 0.78 | MCHR1 (0.41) | MCHR1NPBWR1SLC2A1SLC2A3ALDH1A1 | |
| SCHEMBL11945131 | 0.78 | MAPT (0.38) | MCHR1SLC2A1SLC2A3ALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137179-B1 | PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | MERCK SHARP & DOHME (US) | 2015-09-02 | — | — | EP | disclosed |