Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | BRD7 | Q9NPI1 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.32 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11943804 | 0.84 | MAPT (0.41) | MAPTBRD9CA12CA1CA2 | |
| SCHEMBL14899732 | 0.82 | BRD9 (0.45) | MAPTBRD9CA12CA1CA2 | |
| SCHEMBL17057943 | 0.82 | ALDH1A1 (0.36) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL17058085 | 0.81 | MCHR1 (0.37) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL11943690 | 0.81 | CYP17A1 (0.40) | MAPTBRD9CA12CA1CA2 | |
| SCHEMBL11943800 | 0.81 | CYP17A1 (0.40) | MAPTBRD9CA12CA1CA2 | |
| SCHEMBL11943806 | 0.80 | MAPT (0.41) | MAPTBRD9CA12CA1CA2 | |
| SCHEMBL14899763 | 0.79 | NOS2 (0.38) | MAPTBRD9CYP2C19RAB9ANPC1 | |
| SCHEMBL14081366 | 0.79 | CNR2 (0.33) | MAPTBRD9CA12CA1CA2 | |
| SCHEMBL11943810 | 0.77 | MAPT (0.40) | MAPTBRD9CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2586778-A2 | Pyridazinone derivatives useful as glucan synthase inhibitors | Merck Sharp & Dohme Corp. (US) | 2013-05-01 | — | — | EP | disclosed |