Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | SLC2A2 | P11168 | 1/20 | 0.35 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 8/20 | 0.33 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.33 |
| ▸ | SCN10A | Q9Y5Y9 | 5/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17057968 | 0.88 | SCN9A (0.36) | SLC2A1SLC2A2SLC2A3KDM4ESCN9A | |
| SCHEMBL17058165 | 0.87 | POLB (0.38) | SLC2A1SLC2A2SLC2A3TP53KDM4E | |
| SCHEMBL11945056 | 0.81 | KDM4E (0.58) | HSD17B10KDM4EGLASCN9ASCN10A | |
| SCHEMBL11943944 | 0.80 | ALDH1A1 (0.54) | TP53HSD17B10KDM4EGLASCN9A | |
| SCHEMBL17058435 | 0.80 | SLC2A1 (0.35) | SLC2A1SLC2A2SLC2A3HSD17B10KDM4E | |
| SCHEMBL17058020 | 0.79 | GRM2 (0.38) | SLC2A1SLC2A2SLC2A3TP53HSD17B10 | |
| SCHEMBL17058134 | 0.79 | SLC2A1 (0.37) | SLC2A1SLC2A2SLC2A3HSD17B10KDM4E | |
| SCHEMBL11943936 | 0.79 | KDM4E (0.49) | HSD17B10KDM4EGLASCN9ASCN10A | |
| SCHEMBL17058256 | 0.78 | POLB (0.37) | SLC2A1SLC2A2SLC2A3TP53KDM4E | |
| SCHEMBL17058291 | 0.78 | ALDH1A1 (0.40) | KDM4ESMN1; SMN2LMNAPOLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137179-B1 | PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | MERCK SHARP & DOHME (US) | 2015-09-02 | — | — | EP | disclosed |