Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 3/20 | 0.35 |
| ▸ | SLC2A3 | P11169 | 3/20 | 0.35 |
| ▸ | SLC2A2 | P11168 | 2/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 9/20 | 0.35 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17058134 | 0.90 | SLC2A1 (0.37) | SLC2A1SLC2A3SLC2A2SCN9ASCN10A | |
| SCHEMBL17057968 | 0.88 | SCN9A (0.36) | SLC2A1SLC2A3SLC2A2SCN9ASCN10A | |
| SCHEMBL17057909 | 0.84 | SCN9A (0.38) | SLC2A1SLC2A3SLC2A2SCN9ASCN10A | |
| SCHEMBL11945063 | 0.84 | HSD17B10 (0.44) | SCN9ASCN10AKDM4EMAPTHSD17B10 | |
| SCHEMBL11945066 | 0.82 | ALDH1A1 (0.49) | SCN9ASCN10AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL17058337 | 0.81 | SCN9A (0.36) | SLC2A1SLC2A3SLC2A2SCN9ASCN10A | |
| SCHEMBL14081346 | 0.80 | NPC1 (0.32) | SCN9ASCN10ASMN1; SMN2MAPT | |
| SCHEMBL11945064 | 0.80 | KDM4E (0.55) | SCN9ASCN10AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL17058135 | 0.80 | SLC2A1 (0.35) | SLC2A1SLC2A3SLC2A2SCN9ASCN10A | |
| SCHEMBL17058328 | 0.79 | NPC1 (0.35) | SLC2A1SLC2A3SLC2A2KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137179-B1 | PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | MERCK SHARP & DOHME (US) | 2015-09-02 | — | — | EP | disclosed |