Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | DCTPP1 | Q9H773 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.42 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | NCOA2 | Q15596 | 2/20 | 0.40 |
| ▸ | NCOA1 | Q15788 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17057943 | 0.84 | ALDH1A1 (0.36) | SMN1; SMN2LMNAPOLBKMT2ANPC1 | |
| SCHEMBL17058133 | 0.81 | ALDH1A1 (0.57) | SMN1; SMN2LMNAPOLBKMT2ANPC1 | |
| SCHEMBL17058129 | 0.81 | SMN1; SMN2 (0.49) | SMN1; SMN2LMNAPOLBKMT2ANPC1 | |
| SCHEMBL17057934 | 0.79 | MAPK14 (0.47) | SMN1; SMN2LMNAPOLBKMT2ANPC1 | |
| SCHEMBL17058373 | 0.79 | MAPT (0.46) | SMN1; SMN2LMNAPOLBKMT2ANPC1 | |
| SCHEMBL17058309 | 0.77 | SMN1; SMN2 (0.41) | SMN1; SMN2LMNAPOLBKMT2ANPC1 | |
| SCHEMBL17057914 | 0.76 | SMN1; SMN2 (0.43) | SMN1; SMN2LMNAPOLBKMT2ANPC1 | |
| SCHEMBL17058171 | 0.76 | DCTPP1 (0.47) | SMN1; SMN2LMNAPOLBKMT2ANPC1 | |
| SCHEMBL17057917 | 0.75 | SMN1; SMN2 (0.44) | SMN1; SMN2LMNAPOLBKMT2ANPC1 | |
| SCHEMBL11943995 | 0.74 | MAPT (0.61) | SMN1; SMN2LMNAPOLBKMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137179-B1 | PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | MERCK SHARP & DOHME (US) | 2015-09-02 | — | — | EP | disclosed |