Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 3/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.37 |
| ▸ | CETP | P11597 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | METAP1 | P53582 | 1/20 | 0.33 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17058038 | 0.99 | NPBWR1 (0.36) | NPBWR1MCHR1CETPALDH1A1MAPT | |
| SCHEMBL11945172 | 0.86 | MAPT (0.42) | NPBWR1MCHR1CETPALDH1A1MAPT | |
| SCHEMBL17058188 | 0.86 | NPC1 (0.39) | MCHR1ALDH1A1MAPTDCTPP1POLB | |
| SCHEMBL11944017 | 0.85 | MAPT (0.41) | NPBWR1MCHR1CETPALDH1A1MAPT | |
| SCHEMBL17058048 | 0.85 | PDE4A (0.35) | NPBWR1MCHR1ALDH1A1POLB | |
| SCHEMBL17058429 | 0.82 | SLC2A1 (0.31) | MCHR1 | |
| SCHEMBL17057951 | 0.81 | SLC2A1 (0.34) | MCHR1ALDH1A1MAPTPOLB | |
| SCHEMBL17057874 | 0.81 | NPC1 (0.40) | ALDH1A1MAPTPOLB | |
| SCHEMBL17057993 | 0.79 | RAB9A (0.34) | MCHR1ALDH1A1MAPTDCTPP1RXFP1 | |
| SCHEMBL17058316 | 0.79 | SLC2A1 (0.35) | NPBWR1MCHR1ALDH1A1MAPTDCTPP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137179-B1 | PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | MERCK SHARP & DOHME (US) | 2015-09-02 | — | — | EP | disclosed |