Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.41 |
| ▸ | DCTPP1 | Q9H773 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.38 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.36 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17058023 | 0.88 | NPC1 (0.43) | SMN1; SMN2NPC1RAB9ALMNAPOLB | |
| SCHEMBL11945848 | 0.79 | POLB (0.59) | SMN1; SMN2LMNAPOLBKMT2AALDH1A1 | |
| SCHEMBL17058267 | 0.79 | SMN1; SMN2 (0.43) | SMN1; SMN2NPC1RAB9ALMNAPOLB | |
| SCHEMBL17057942 | 0.78 | POLB (0.42) | SMN1; SMN2NPC1RAB9ALMNAPOLB | |
| SCHEMBL17058260 | 0.78 | POLB (0.41) | SMN1; SMN2NPC1RAB9ALMNAPOLB | |
| SCHEMBL17057912 | 0.77 | SMN1; SMN2 (0.41) | SMN1; SMN2NPC1RAB9ALMNAPOLB | |
| SCHEMBL11944070 | 0.77 | NPSR1 (0.40) | SMN1; SMN2LMNAPOLBKMT2AALDH1A1 | |
| SCHEMBL11945840 | 0.77 | POLB (0.50) | SMN1; SMN2NPC1RAB9ALMNAPOLB | |
| SCHEMBL17057993 | 0.77 | RAB9A (0.34) | SMN1; SMN2NPC1RAB9ALMNAPOLB | |
| SCHEMBL11945838 | 0.77 | TP53 (0.47) | SMN1; SMN2LMNAPOLBALDH1A1DCTPP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137179-B1 | PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | MERCK SHARP & DOHME (US) | 2015-09-02 | — | — | EP | disclosed |