Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | DCTPP1 | Q9H773 | 2/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.30 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11945627 | 0.79 | POLB (0.46) | SMN1; SMN2POLBLMNAKMT2AMAPT | |
| SCHEMBL17058207 | 0.79 | NPSR1 (0.38) | NPC1RAB9ASMN1; SMN2POLBLMNA | |
| SCHEMBL17058168 | 0.74 | MAPT (0.40) | NPC1RAB9ASMN1; SMN2POLBLMNA | |
| SCHEMBL17058221 | 0.74 | ALDH1A1 (0.32) | NPC1RAB9ASMN1; SMN2POLBLMNA | |
| SCHEMBL17058105 | 0.73 | SMN1; SMN2 (0.43) | NPC1RAB9ASMN1; SMN2POLBLMNA | |
| SCHEMBL17058531 | 0.73 | ALDH1A1 (0.34) | NPC1RAB9ASMN1; SMN2POLBLMNA | |
| SCHEMBL17058119 | 0.73 | SMN1; SMN2 (0.41) | NPC1RAB9ASMN1; SMN2POLBLMNA | |
| SCHEMBL11945629 | 0.73 | POLB (0.45) | SMN1; SMN2POLBLMNAKMT2AMAPT | |
| SCHEMBL17058297 | 0.72 | SMN1; SMN2 (0.39) | NPC1RAB9ASMN1; SMN2POLBLMNA | |
| SCHEMBL17058120 | 0.72 | NPC1 (0.37) | NPC1RAB9ASMN1; SMN2POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137179-B1 | PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | MERCK SHARP & DOHME (US) | 2015-09-02 | — | — | EP | disclosed |