Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 3/20 | 0.35 |
| ▸ | SLC2A3 | P11169 | 3/20 | 0.35 |
| ▸ | SLC2A2 | P11168 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17058161 | 0.90 | SCN9A (0.38) | SCN9ASMN1; SMN2SLC2A1SLC2A3SLC2A2 | |
| SCHEMBL17058243 | 0.88 | ALDH1A1 (0.36) | SMN1; SMN2SLC2A1SLC2A3LMNAGAA | |
| SCHEMBL17058153 | 0.88 | SCN9A (0.40) | SCN9ASMN1; SMN2SLC2A1SLC2A3SLC2A2 | |
| SCHEMBL17058284 | 0.87 | SLC2A1 (0.38) | SMN1; SMN2SLC2A1SLC2A3SLC2A2LMNA | |
| SCHEMBL17058031 | 0.84 | MAPT (0.41) | SMN1; SMN2LMNAGAAALDH1A1DCTPP1 | |
| SCHEMBL11943957 | 0.84 | HSD17B10 (0.46) | SCN9ASMN1; SMN2LMNAGAAHTT | |
| SCHEMBL11945079 | 0.82 | ALDH1A1 (0.51) | SCN9ASMN1; SMN2LMNAGAAHTT | |
| SCHEMBL17058177 | 0.81 | SCN9A (0.35) | SCN9ASMN1; SMN2SLC2A1SLC2A3SLC2A2 | |
| SCHEMBL11943958 | 0.80 | HSD17B10 (0.43) | SCN9ASMN1; SMN2LMNAGAAHTT | |
| SCHEMBL11945080 | 0.80 | KDM4E (0.57) | SCN9ASMN1; SMN2LMNAGAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137179-B1 | PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | MERCK SHARP & DOHME (US) | 2015-09-02 | — | — | EP | disclosed |