Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 6/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | SLC2A2 | P11168 | 1/20 | 0.35 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.33 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17058249 | 0.90 | SCN9A (0.37) | SCN9ASLC2A1SLC2A2SLC2A3LMNA | |
| SCHEMBL17058153 | 0.89 | SCN9A (0.40) | SCN9ASLC2A1SLC2A2SLC2A3LMNA | |
| SCHEMBL17058394 | 0.86 | POLB (0.39) | SLC2A1SLC2A2SLC2A3LMNAKDM4E | |
| SCHEMBL11945079 | 0.84 | ALDH1A1 (0.51) | SCN9ALMNAGAAHTTHSD17B10 | |
| SCHEMBL11945080 | 0.83 | KDM4E (0.57) | SCN9ALMNAGAAHTTHSD17B10 | |
| SCHEMBL17058399 | 0.82 | POLB (0.42) | HTTKDM4ESMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL17058337 | 0.82 | SCN9A (0.36) | SCN9ASLC2A1SLC2A2SLC2A3HSD17B10 | |
| SCHEMBL11943958 | 0.81 | HSD17B10 (0.43) | SCN9ALMNAGAAHTTHSD17B10 | |
| SCHEMBL11943957 | 0.80 | HSD17B10 (0.46) | SCN9ALMNAGAAHTTHSD17B10 | |
| SCHEMBL17058243 | 0.78 | ALDH1A1 (0.36) | SLC2A1SLC2A3LMNAGAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137179-B1 | PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | MERCK SHARP & DOHME (US) | 2015-09-02 | — | — | EP | disclosed |