Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HA1 | P13674 | 2/20 | 0.46 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.46 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.41 |
| ▸ | LDHA | P00338 | 1/20 | 0.40 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.36 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17059686 | 0.86 | P4HA1 (0.66) | P4HA1P4HTMLDHABAZ2BNPC1 | |
| SCHEMBL30626041 | 0.82 | P4HTM (0.64) | P4HA1P4HTMKCNJ1LDHABAZ2B | |
| SCHEMBL29123392 | 0.82 | P4HTM (0.64) | P4HA1P4HTMKCNJ1LDHABAZ2B | |
| SCHEMBL17059095 | 0.82 | P4HA1 (0.46) | P4HA1P4HTMKCNJ1LDHABAZ2B | |
| SCHEMBL15750222 | 0.77 | TDP1 (0.44) | P4HTMRXFP1NPC1TSHRMAPT | |
| SCHEMBL12436558 | 0.76 | LDHA (0.56) | P4HA1P4HTMKCNJ1LDHABAZ2B | |
| SCHEMBL26014757 | 0.76 | KDM4E (0.48) | BAZ2BALDH1A1L3MBTL1KMT2A | |
| SCHEMBL16991665 | 0.75 | NPC1 (0.51) | P4HA1P4HTMLDHABAZ2BRXFP1 | |
| SCHEMBL25261607 | 0.75 | P4HA1 (0.79) | P4HA1P4HTMLDHANPC1TSHR | |
| SCHEMBL30448448 | 0.75 | P4HA1 (0.79) | P4HA1P4HTMLDHANPC1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9902705-B2 | Functionalized 1,2,4,5-tetrazine compounds for use in bioorthogonal coupling reactions | THE GENERAL HOSPITAL CORPORATION (US) | 2018-02-27 | — | — | US | disclosed |
| US-20150246893-A1 | FUNCTIONALIZED 1,2,4,5-TETRAZINE COMPOUNDS FOR USE IN BIOORTHOGONAL COUPLING REACTIONS | THE GENERAL HOSPITAL CORPORATION (US) | 2015-09-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150246893-A1 | FUNCTIONALIZED 1,2,4,5-TETRAZINE COMPOUNDS FOR USE IN BIOORTHOGONAL COUPLING REACTIONS | TIE1, TTL, EPHA2 | P4HA1 2904/4885P4HTM 2114/4885KCNJ1 4661/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.