Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
| ▸ | CCR8 | P51685 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14717415 | 0.82 | SMN1; SMN2 (0.41) | SMN1; SMN2KDM4EMAPTALDH1A1HPGD | |
| SCHEMBL2594547 | 0.82 | SMN1; SMN2 (0.41) | SMN1; SMN2KDM4EMAPTCYP1A2LMNA | |
| SCHEMBL16289923 | 0.81 | SMN1; SMN2 (0.66) | SMN1; SMN2KDM4EMAPTNPC1HCRTR1 | |
| SCHEMBL12702866 | 0.74 | SMN1; SMN2 (0.49) | SMN1; SMN2KDM4EMAPTNPC1HCRTR1 | |
| SCHEMBL29847401 | 0.72 | HTR1A (0.58) | SMN1; SMN2KDM4EMAPTNPC1HCRTR1 | |
| SCHEMBL873431 | 0.72 | HTR1A (0.58) | SMN1; SMN2KDM4EMAPTNPC1HCRTR1 | |
| SCHEMBL14706907 | 0.72 | SMN1; SMN2 (0.39) | SMN1; SMN2MAPTALDH1A1CYP1A2LMNA | |
| SCHEMBL8603400 | 0.72 | NR4A2 (0.40) | KDM4EMAPTALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL24347834 | 0.71 | SMN1; SMN2 (0.47) | SMN1; SMN2KDM4EMAPTNPC1HCRTR1 | |
| SCHEMBL13562374 | 0.71 | UHRF1 (0.46) | SMN1; SMN2KDM4EMAPTTSHRCCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566477-B1 | AMINO-QUINOLINES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2015-09-02 | — | — | EP | disclosed |