Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 9/20 | 0.54 |
| ▸ | MEN1 | O00255 | 8/20 | 0.51 |
| ▸ | HTT | P42858 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | BAZ1A | Q9NRL2 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | DDX3X | O00571 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.50 |
| ▸ | MET | P08581 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 3/20 | 0.48 |
| ▸ | BCR | P11274 | 3/20 | 0.48 |
| ▸ | PRKCA | P17252 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17059658 | 0.85 | CSNK1A1 (0.58) | KMT2AMEN1HTTMAPTLMNA | |
| SCHEMBL27877544 | 0.84 | MEN1 (0.71) | KMT2AMEN1HTTMAPTLMNA | |
| SCHEMBL17059649 | 0.84 | EGFR (0.57) | KMT2AMEN1HTTMAPTLMNA | |
| SCHEMBL17059660 | 0.82 | EGFR (0.68) | CSNK1A1EGFR | |
| SCHEMBL17059598 | 0.81 | EGFR (0.69) | KMT2AMEN1HTTMAPTLMNA | |
| SCHEMBL17059595 | 0.80 | KMT2A (0.64) | KMT2AMEN1HTTMAPTLMNA | |
| SCHEMBL17059603 | 0.78 | EGFR (0.60) | KMT2AMEN1HTTMAPTLMNA | |
| SCHEMBL17059681 | 0.77 | EGFR (0.72) | KMT2ALMNAALDH1A1SMN1; SMN2EGFR | |
| SCHEMBL17059645 | 0.75 | KMT2A (0.57) | KMT2AMEN1HTTMAPTLMNA | |
| SCHEMBL17059594 | 0.75 | EGFR (0.58) | KMT2AMEN1HTTMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015127873-A1 | ARYLAMINO PYRAMIDINE COMPOUND AND APPLICATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS AND PHARMACEUTICALLY ACCEPTABLE COMPOSITIONS PREPARED THEREFROM | 上海海雁医药科技有限公司 | 2015-09-03 | — | — | WO | disclosed |