Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.57 |
| ▸ | ERBB2 | P04626 | 13/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | PPIA | P62937 | 1/20 | 0.49 |
| ▸ | MET | P08581 | 1/20 | 0.48 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17059641 | 0.88 | EGFR (0.55) | EGFRERBB2ERBB4 | |
| SCHEMBL17059626 | 0.85 | EGFR (0.62) | EGFRERBB2ERBB4 | |
| SCHEMBL17059657 | 0.84 | KMT2A (0.54) | EGFRMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL17059598 | 0.73 | EGFR (0.69) | EGFRMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL141880 | 0.73 | EGFR (0.59) | EGFRERBB2MEN1ALDH1A1LMNA | |
| SCHEMBL29555766 | 0.73 | EGFR (0.59) | EGFRERBB2MEN1ALDH1A1LMNA | |
| SCHEMBL28081958 | 0.72 | EGFR (0.51) | EGFRERBB2MEN1ALDH1A1KMT2A | |
| SCHEMBL17059595 | 0.72 | KMT2A (0.64) | MEN1ALDH1A1LMNAMAPTMAPK1 | |
| SCHEMBL233118 | 0.72 | EGFR (0.70) | EGFRERBB2ERBB4 | |
| SCHEMBL18788863 | 0.71 | EGFR (0.61) | EGFRERBB2ERBB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015127873-A1 | ARYLAMINO PYRAMIDINE COMPOUND AND APPLICATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS AND PHARMACEUTICALLY ACCEPTABLE COMPOSITIONS PREPARED THEREFROM | 上海海雁医药科技有限公司 | 2015-09-03 | — | — | WO | disclosed |