Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.64 |
| ▸ | MEN1 | O00255 | 7/20 | 0.64 |
| ▸ | MAPT | P10636 | 5/20 | 0.64 |
| ▸ | HTT | P42858 | 4/20 | 0.64 |
| ▸ | POLB | P06746 | 3/20 | 0.64 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.64 |
| ▸ | DDX3X | O00571 | 2/20 | 0.64 |
| ▸ | BAZ1A | Q9NRL2 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | CNR1 | P21554 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | CA12 | O43570 | 2/20 | 0.52 |
| ▸ | CA1 | P00915 | 2/20 | 0.52 |
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | CA9 | Q16790 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13859262 | 0.84 | ROCK1 (0.72) | KMT2AMEN1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL1047211 | 0.80 | MEN1 (1.00) | KMT2AMEN1MAPTHTTPOLB | |
| SCHEMBL17059591 | 0.80 | DDX3X (0.60) | KMT2AMEN1MAPTHTTPOLB | |
| SCHEMBL17059657 | 0.80 | KMT2A (0.54) | KMT2AMEN1MAPTHTTPOLB | |
| SCHEMBL17084065 | 0.79 | MEN1 (0.96) | KMT2AMEN1MAPTHTTPOLB | |
| SCHEMBL29494959 | 0.78 | MAPT (0.82) | KMT2AMEN1MAPTHTTPOLB | |
| SCHEMBL22092648 | 0.78 | MAPT (0.82) | KMT2AMEN1MAPTHTTPOLB | |
| SCHEMBL23065786 | 0.77 | KMT2A (0.62) | KMT2AMEN1MAPTHTTNPC1 | |
| SCHEMBL17059588 | 0.77 | EGFR (0.61) | — | |
| SCHEMBL17059598 | 0.77 | EGFR (0.69) | KMT2AMEN1MAPTHTTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015127873-A1 | ARYLAMINO PYRAMIDINE COMPOUND AND APPLICATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS AND PHARMACEUTICALLY ACCEPTABLE COMPOSITIONS PREPARED THEREFROM | 上海海雁医药科技有限公司 | 2015-09-03 | — | — | WO | disclosed |