Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 7/20 | 0.51 |
| ▸ | ITK | Q08881 | 3/20 | 0.47 |
| ▸ | EGFR | P00533 | 9/20 | 0.44 |
| ▸ | TGM2 | P21980 | 1/20 | 0.43 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17059664 | 0.82 | CTPS1 (0.46) | CTPS1 | |
| SCHEMBL17059588 | 0.77 | EGFR (0.61) | BTKITKEGFR | |
| SCHEMBL23899138 | 0.74 | MAP2K7 (0.59) | BTKITKEGFR | |
| SCHEMBL3697492 | 0.73 | BTK (0.56) | BTKITKEGFRTGM2JAK3 | |
| SCHEMBL4103284 | 0.71 | TGM2 (0.76) | BTKITKEGFRTGM2JAK3 | |
| SCHEMBL28400866 | 0.71 | EGFR (0.61) | BTKITKEGFR | |
| SCHEMBL30423172 | 0.71 | EGFR (0.61) | BTKITKEGFR | |
| SCHEMBL9923766 | 0.70 | BTK (0.74) | BTKITKEGFR | |
| SCHEMBL18396624 | 0.70 | BTK (0.51) | BTKITKEGFRTGM2JAK3 | |
| SCHEMBL9945478 | 0.70 | BTK (0.67) | BTKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105683168-B | Fragrant amino pyrimidines and its application and pharmaceutical composition prepared therefrom and Pharmaceutical composition | 上海海雁医药科技有限公司 | 2017-12-08 | — | — | CN | disclosed |
| CN-104860891-B | Fragrant amino pyrimidines and its application and pharmaceutical composition prepared therefrom and Pharmaceutical composition | 上海海雁医药科技有限公司 | 2017-06-30 | — | — | CN | disclosed |
| CN-105683168-A | Arylamino pyramidine compound and application thereof, and pharmaceutical compositions and pharmaceutically acceptable compositions prepared therefrom | 上海海雁医药科技有限公司 | 2016-06-15 | — | — | CN | disclosed |
| WO-2015127873-A1 | ARYLAMINO PYRAMIDINE COMPOUND AND APPLICATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS AND PHARMACEUTICALLY ACCEPTABLE COMPOSITIONS PREPARED THEREFROM | 上海海雁医药科技有限公司 | 2015-09-03 | — | — | WO | disclosed |