Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | GABRP | O00591 | 3/20 | 0.42 |
| ▸ | GABRD | O14764 | 3/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.42 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.42 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.42 |
| ▸ | GABRE | P78334 | 3/20 | 0.42 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.42 |
| ▸ | GABRG1 | Q8N1C3 | 3/20 | 0.42 |
| ▸ | GABRG3 | Q99928 | 3/20 | 0.42 |
| ▸ | GABRQ | Q9UN88 | 3/20 | 0.42 |
| ▸ | TDO2 | P48775 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carbazole SCHEMBL28524971 | 0.79 | ALDH1A1 (0.67) | ALDH1A1KDM4EGABRPGABRDGABRA1 | |
| Carbazole SCHEMBL29044867 | 0.79 | ALDH1A1 (0.67) | ALDH1A1KDM4EGABRPGABRDGABRA1 | |
| Carbazole SCHEMBL16762987 | 0.79 | ALDH1A1 (0.67) | ALDH1A1KDM4EGABRPGABRDGABRA1 | |
| Carbazole SCHEMBL27968093 | 0.79 | ALDH1A1 (0.67) | ALDH1A1KDM4EGABRPGABRDGABRA1 | |
| Carbazole SCHEMBL3120699 | 0.79 | ALDH1A1 (0.67) | ALDH1A1KDM4EGABRPGABRDGABRA1 | |
| Carbazole SCHEMBL28593654 | 0.79 | ALDH1A1 (0.67) | ALDH1A1KDM4EGABRPGABRDGABRA1 | |
| Carbazole SCHEMBL28579600 | 0.77 | ALDH1A1 (0.64) | ALDH1A1KDM4EGABRPGABRDGABRA1 | |
| Carbazole SCHEMBL27973136 | 0.77 | ALDH1A1 (0.64) | ALDH1A1KDM4EGABRPGABRDGABRA1 | |
| Carbazole SCHEMBL27902399 | 0.76 | ALDH1A1 (0.49) | ALDH1A1KDM4EGABRPGABRDGABRA1 | |
| SCHEMBL170598 | 0.75 | TDO2 (0.42) | ALDH1A1KDM4EGABRPGABRDGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 271 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2993226-B1 | GROWTH FACTORS FOR PRODUCTION OF DEFINITIVE ENDODERM | VIACYTE INC (US) | 2020-12-16 | — | — | EP | claimed |
| US-10294457-B2 | Maturation of hepatocyte-like cells derived from human pluripotent stem cells | TAKARA BIO EUROPE AB (SE) | 2019-05-21 | — | — | US | claimed |
| US-20170189496-A1 | USE OF PHOSPHORYLATION PATHWAY-RELATED FACTOR IN REGULATING FUNCTION OF REGULATORY T CELL | INSTITUT PASTEUR OF SHANGHAI, CHINESE ACADEMY OF SCIENCES (CN) | 2017-07-06 | — | — | US | claimed |
| EP-2550355-B1 | DIRECTED DIFFERENTIATION AND MATURATION OF PLURIPOTENT CELLS INTO HEPATOCYTE LIKE CELLS BY MODULATION OF WNT-SIGNALLING PATHWAY | TAKARA BIO EUROP AB (SE) | 2016-11-16 | — | — | EP | claimed |
| US-20160237405-A1 | DIFFERENTIATION OF HUMAN PLURIPOTENT STEM CELLS TO MULTIPOTENT NEURAL CREST CELLS | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. | 2016-08-18 | — | — | US | claimed |
| US-9394522-B2 | Directed differentiation and maturation of pluripotent cells into hepatocyte like cells by modulation of Wnt-signalling pathway | TAKARA BIO EUROPE AB (SE) | 2016-07-19 | — | — | US | claimed |
| EP-2993226-A1 | GROWTH FACTORS FOR PRODUCTION OF DEFINITIVE ENDODERM | VIACYTE, INC. (US) | 2016-03-09 | — | — | EP | claimed |
| US-9175260-B2 | Early mesoderm cells, a stable population of mesendoderm cells that has utility for generation of endoderm and mesoderm lineages and multipotent migratory cells (MMC) | TheUniversity of Georgia Research Foundation, Inc. (US) | 2015-11-03 | — | — | US | claimed |
| US-20150307839-A1 | MATURATION OF HEPATOCYTE-LIKE CELLS DERIVED FROM HUMAN PLURIPOTENT STEM CELLS | TAKARA BIO EUROPE AB (SE) | 2015-10-29 | — | — | US | claimed |
| EP-2297319-B1 | GROWTH FACTORS FOR PRODUCTION OF DEFINITIVE ENDODERM | VIACYTE INC (US) | 2015-10-07 | — | — | EP | claimed |
| US-20130095567-A1 | DIRECTED DIFFERENTIATION AND MATURATION OF PLURIPOTENT CELLS INTO HEPATOCYTE LIKE CELLS BY MODULATION OF WNT-SIGNALLING PATHWAY | CELLARTIS AB (SE) | 2013-04-18 | — | — | US | claimed |
| EP-2550355-A1 | DIRECTED DIFFERENTIATION AND MATURATION OF PLURIPOTENT CELLS INTO HEPATOCYTE LIKE CELLS BY MODULATION OF WNT-SIGNALLING PATHWAY | Cellartis AB (SE) | 2013-01-30 | — | — | EP | claimed |
| WO-2011116930-A1 | DIRECTED DIFFERENTIATION AND MATURATION OF PLURIPOTENT CELLS INTO HEPATOCYTE LIKE CELLS BY MODULATION OF WNT-SIGNALLING PATHWAY | CELLARTIS AB (SE) | 2011-09-29 | — | — | WO | claimed |
| EP-2297319-A1 | GROWTH FACTORS FOR PRODUCTION OF DEFINITIVE ENDODERM | Cythera Inc. (US) | 2011-03-23 | — | — | EP | claimed |
| WO-2010108005-A2 | NOVEL NEURAL PROGENITORS FROM PLURIPOTENT STEM CELLS, METHODS OF PRODUCING SAME AND USE TO PRODUCE NEURAL CELLS | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION (US) | 2010-09-23 | — | — | WO | claimed |
| US-20100166713-A1 | EARLY MESODERM CELLS, A STABLE POPULATION OF MESENDODERM CELLS THAT HAS UTILITY FOR GENERATION OF ENDODERM AND MESODERM LINEAGES AND MULTIPOTENT MIGRATORY CELLS (MMC) | THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. | 2010-07-01 | — | — | US | claimed |
| WO-2009154606-A1 | GROWTH FACTORS FOR PRODUCTION OF DEFINITIVE ENDODERM | CYTHERA, INC. (US) | 2009-12-23 | — | — | WO | claimed |
| US-20090298178-A1 | GROWTH FACTORS FOR PRODUCTION OF DEFINITIVE ENDODERM | D AMOUR KEVIN ALLEN | 2009-12-03 | — | — | US | claimed |
| EP-2126045-A2 | EARLY MESODERM CELLS, A STABLE POPULATION OF MESENDODERM CELLS THAT HAS UTILITY FOR GENERATION OF ENDODERM AND MESODERM LINEAGES AND MULTIPOTENT MIGRATORY CELLS (MMC) | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 2009-12-02 | — | — | EP | claimed |
| WO-2008094597-A2 | EARLY MESODERM CELLS, A STABLE POPULATION OF MESENDODERM CELLS THAT HAS UTILITY FOR GENERATION OF ENDODERM AND MESODERM LINEAGES AND MULTIPOTENT MIGRATORY CELLS (MMC) | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 2008-08-07 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170189496-A1 | USE OF PHOSPHORYLATION PATHWAY-RELATED FACTOR IN REGULATING FUNCTION OF REGULATORY T CELL | NFATC1, PIM1, PIM2 | ALDH1A1 4612/4885KDM4E 2018/4885GABRP 406/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.