Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK7 | Q13164 | 6/20 | 0.54 |
| ▸ | BRD4 | O60885 | 3/20 | 0.54 |
| ▸ | TTR | P02766 | 2/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
| ▸ | DCLK1 | O15075 | 3/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.42 |
| ▸ | AURKA | O14965 | 3/20 | 0.42 |
| ▸ | PIK3C2G | O75747 | 3/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18379111 | 0.85 | MAPK7 (0.54) | MAPK7BRD4TTRCES1DRD2 | |
| SCHEMBL17059738 | 0.84 | DCLK1 (0.45) | MAPK7BRD4TTRCES1DRD2 | |
| SCHEMBL22137443 | 0.84 | MAPK7 (0.55) | MAPK7BRD4TTRCES1DRD2 | |
| SCHEMBL18369919 | 0.79 | MAPK7 (0.56) | MAPK7BRD4DCLK1PIK3CDAURKA | |
| SCHEMBL17059740 | 0.77 | MAPK7 (0.42) | MAPK7BRD4TTRCES1LRRK2 | |
| SCHEMBL17059742 | 0.77 | MAPK7 (0.57) | MAPK7BRD4TTRCES1DRD2 | |
| SCHEMBL12059596 | 0.77 | TTR (0.69) | TTRCES1DRD2HTR6LRRK2 | |
| SCHEMBL16127516 | 0.77 | TTR (0.75) | TTRCES1DRD2HTR6LRRK2 | |
| SCHEMBL17059747 | 0.76 | MAPT (0.46) | LMNAMAPTALDH1A1HPGD | |
| SCHEMBL10098691 | 0.75 | MAPK7 (0.56) | MAPK7BRD4TTRCES1DCLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210070731-A1 | TRICYCLIC KINASE INHIBITORS AND USE THEREOF | NAMDEV NIVEDITA (US) | 2021-03-11 | — | — | US | disclosed |
| US-20170008888-A1 | HETEROCYCLIC COMPOUNDS | ACTIVX BIOSCIENCES, INC. | 2017-01-12 | — | — | US | disclosed |
| US-20170008888-A1 | HETEROCYCLIC COMPOUNDS | ACTIVX BIOSCIENCES, INC. | 2017-01-12 | — | — | US | disclosed |
| WO-2015129927-A1 | HETEROCYCLIC COMPOUNDS | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2015-09-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170008888-A1 | HETEROCYCLIC COMPOUNDS | BET1, EP300, RBBP5 | MAPK7 58/4885BRD4 4/4885TTR 4074/4885 |
| US-20210070731-A1 | TRICYCLIC KINASE INHIBITORS AND USE THEREOF | MARK3, MARK2, MARK1 | MAPK7 114/4885BRD4 1207/4885TTR 4838/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.