Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK7 | Q13164 | 6/20 | 0.54 |
| ▸ | BRD4 | O60885 | 4/20 | 0.54 |
| ▸ | TTR | P02766 | 2/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.46 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.44 |
| ▸ | AURKA | O14965 | 3/20 | 0.44 |
| ▸ | PIK3C2G | O75747 | 3/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.44 |
| ▸ | DCLK1 | O15075 | 3/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17059804 | 0.85 | MAPK7 (0.54) | MAPK7BRD4TTRCES1NR1H2 | |
| SCHEMBL22137443 | 0.84 | MAPK7 (0.55) | MAPK7BRD4TTRCES1NR1H2 | |
| SCHEMBL18369919 | 0.79 | MAPK7 (0.56) | MAPK7BRD4PIK3CDAURKAPIK3C2G | |
| SCHEMBL12059596 | 0.77 | TTR (0.69) | TTRCES1NR1H2NR1H3LRRK2 | |
| SCHEMBL18369886 | 0.77 | MAPK7 (0.57) | MAPK7BRD4TTRCES1PIK3CD | |
| SCHEMBL16127516 | 0.77 | TTR (0.75) | TTRCES1NR1H2NR1H3LRRK2 | |
| SCHEMBL10098766 | 0.75 | DCLK1 (0.58) | MAPK7BRD4TTRCES1PIK3CD | |
| SCHEMBL18369826 | 0.74 | MAPK7 (0.54) | MAPK7BRD4PIK3CDAURKAPIK3C2G | |
| SCHEMBL17059849 | 0.74 | MAPK7 (0.72) | MAPK7BRD4PIK3CDAURKAPIK3C2G | |
| SCHEMBL18369845 | 0.74 | MAPK7 (0.54) | MAPK7BRD4DCLK1LRRK2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170008888-A1 | HETEROCYCLIC COMPOUNDS | ACTIVX BIOSCIENCES, INC. | 2017-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170008888-A1 | HETEROCYCLIC COMPOUNDS | BET1, EP300, RBBP5 | MAPK7 58/4885BRD4 4/4885TTR 4074/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.