Sugi Predict

Sugi Predict / Compounds / SCHEMBL1706188

SCHEMBL1706188

SCHEMBL1706188

Cc1cc2ccccc2nc1Nc1ccccc1OC(F)(F)F

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ EPHX2 P34913 1/20 0.48
▸ C1R P00736 1/20 0.47
▸ ALPL P05186 2/20 0.41
▸ ALDH1A1 P00352 3/20 0.40
▸ TDP1 Q9NUW8 3/20 0.40
▸ GAA P10253 2/20 0.40
▸ MEN1 O00255 2/20 0.40
▸ KMT2A Q03164 2/20 0.40
▸ NPSR1 Q6W5P4 1/20 0.40
▸ RXFP1 Q9HBX9 1/20 0.40
▸ MAPT P10636 4/20 0.39
▸ KDM4E B2RXH2 3/20 0.39
▸ CASP7 P55210 2/20 0.39
▸ LMNA P02545 2/20 0.39
▸ HSD17B10 Q99714 2/20 0.39
▸ ALOX15 P16050 1/20 0.39
▸ CASP1 P29466 1/20 0.39
▸ RUNX1 Q01196 1/20 0.39
▸ CBFB Q13951 1/20 0.39
▸ CASP3 P42574 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1702147 0.82 MAPT (0.46) ALPLALDH1A1GAAMEN1KMT2A
SCHEMBL1702525 0.80 IGF1R (0.53) EPHX2ALDH1A1MEN1KMT2AMAPT
SCHEMBL1706301 0.79 SMN1; SMN2 (0.51) EPHX2MEN1KMT2AMAPTTP53
Hydrochloric Acid SCHEMBL13517466 0.78 SMN1; SMN2 (0.50) EPHX2MEN1KMT2AMAPTLMNA
SCHEMBL1702231 0.75 NPC1 (0.54) EPHX2C1RALPLALDH1A1GAA
SCHEMBL17208353 0.75 TRPA1 (0.42) ALPLTDP1MEN1KMT2AMAPT
SCHEMBL3192934 0.73 EPHX2 (0.57) EPHX2C1RALDH1A1GAANPSR1
SCHEMBL30754743 0.72 EPHX2 (0.58) EPHX2C1RGAAMEN1KMT2A
SCHEMBL22543002 0.72 EPHX2 (0.58) EPHX2C1RGAAMEN1KMT2A
SCHEMBL9095962 0.70 LMNA (0.46) EPHX2C1RTDP1GAAMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 129 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2440546-B1 COMPOUNDS USEFUL FOR TREATING PREMATURE AGING AND IN PARTICULAR PROGERIA ABIVAX (FR) 2022-12-28 — — EP claimed
EP-2440547-B1 New chemical molecules that inhibit the splicing mechanism for the treatment of diseases resulting from splicing defects ABIVAX (FR) 2022-11-30 — — EP claimed
EP-3517534-A1 COMPOUNDS USEFUL FOR TREATING CANCER ABIVAX (FR) 2019-07-31 — — EP claimed
US-10017498-B2 Compounds useful for treating AIDS ABIVAX (FR) 2018-07-10 — — US claimed
US-9827237-B2 Compounds useful for treating diseases caused by retroviruses ABIVAX (FR) 2017-11-28 — — US claimed
US-20160151348-A1 COMPOUNDS USEFUL FOR TREATING DISEASES CAUSED BY RETROVIRUSES ABIVAX (FR) 2016-06-02 — — US claimed
EP-3016656-A1 BICYCLIC COMPOUNDS USEFUL FOR TREATING DISEASES CAUSED BY RETROVIRUSES ABIVAX (FR) 2016-05-11 — — EP claimed
CN-105530938-A Compounds for the treatment of diseases caused by retroviruses ABIVAX 2016-04-27 — — CN claimed
US-20150307478-A1 COMPOUNDS USEFUL FOR TREATING AIDS UNIVERSITE DE MONTPELLIER (FR) 2015-10-29 — — US claimed
CN-104945378-A Compounds for the treatment of premature aging and especially premature aging ABIVAX 2015-09-30 — — CN claimed
US-9145367-B2 Compounds useful for treating AIDS ABIVAX (FR) 2015-09-29 — — US claimed
US-9108919-B2 Compounds useful for treating cancer ABIVAX (FR) 2015-08-18 — — US claimed
WO-2015001518-A1 BICYCLIC COMPOUNDS USEFUL FOR TREATING DISEASES CAUSED BY RETROVIRUSES SPLICOS (FR) 2015-01-08 — — WO claimed
US-20140080831-A1 COMPOUNDS USEFUL FOR TREATING CANCER CENTRE NATIONALE DE RECHERCHE SCIENTIFIQUE (FR) 2014-03-20 — — US claimed
US-20120329796-A1 COMPOUNDS USEFUL FOR TREATING PREMATURE AGING AND IN PARTICULAR PROGERIA SOCIETE SPLICOS (FR) 2012-12-27 — — US claimed
US-20120283265-A1 COMPOUNDS USEFUL FOR TREATING AIDS SOCIETE SPLICOS (FR) 2012-11-08 — — US claimed
US-20120277230-A1 COMPOUNDS USEFUL FOR TREATING CANCER SOCIETE SPLICOS (FR) 2012-11-01 — — US claimed
CN-102625804-A Compounds for the treatment of AIDS SPLICOS SOC 2012-08-01 — — CN claimed
CN-102596935-A Compounds for the treatment of premature aging and especially premature aging SPLICOS SOC 2012-07-18 — — CN claimed
CN-102574835-A Compounds for the treatment of cancer SPLICOS SOC 2012-07-11 — — CN claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10017498-B2 Compounds useful for treating AIDS NR1H3, NR1H2, NR1H4 EPHX2 2078/4885C1R 84/4885ALPL 4860/4885
US-20120283265-A1 COMPOUNDS USEFUL FOR TREATING AIDS CBR1, CNR1, CBR3 EPHX2 942/4885C1R 33/4885ALPL 4857/4885
US-20120277230-A1 COMPOUNDS USEFUL FOR TREATING CANCER CBR1, CBR3, NCOR1 EPHX2 1415/4885C1R 100/4885ALPL 4878/4885
US-20120329796-A1 COMPOUNDS USEFUL FOR TREATING PREMATURE AGING AND IN PARTICULAR PROGERIA NR2C2, NCOR2, NR4A2 EPHX2 2649/4885C1R 355/4885ALPL 4770/4885
US-20150307478-A1 COMPOUNDS USEFUL FOR TREATING AIDS NR1H3, NR1H2, NR1H4 EPHX2 2078/4885C1R 84/4885ALPL 4860/4885
US-20160151348-A1 COMPOUNDS USEFUL FOR TREATING DISEASES CAUSED BY RETROVIRUSES RCOR1, CBR1, RCOR3 EPHX2 1556/4885C1R 39/4885ALPL 4870/4885
US-20140080831-A1 COMPOUNDS USEFUL FOR TREATING CANCER NR1H4, NR1H3, NCOR1 EPHX2 2761/4885C1R 276/4885ALPL 4857/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.