Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 4/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.48 |
| ▸ | TNF | P01375 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.43 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.42 |
| ▸ | VNN1 | O95497 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 3/20 | 0.40 |
| ▸ | CNR2 | P34972 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL934609 | 0.85 | ADRA1D (0.50) | ADRA1DADRA1AADRA2BADRA1BTNF | |
| SCHEMBL28876484 | 0.83 | ADRA1D (0.44) | ADRA1DADRA1AADRA2BADRA1BTNF | |
| SCHEMBL6390843 | 0.80 | TNF (0.52) | ADRA1DADRA1AADRA2BADRA1BTNF | |
| SCHEMBL1022809 | 0.78 | ENPP2 (0.44) | ADRA1DADRA1AADRA2BADRA1BTNF | |
| SCHEMBL1990381 | 0.77 | PTGS1 (0.54) | ADRA1DADRA1AADRA2BADRA1BGSK3B | |
| SCHEMBL214901 | 0.75 | ENPP2 (0.46) | ADRA1DADRA1AADRA2BADRA1BTNF | |
| SCHEMBL1719895 | 0.75 | GLA (0.44) | ADRA1DADRA1AADRA2BADRA1BTNF | |
| SCHEMBL320196 | 0.75 | ENPP2 (0.46) | ADRA1DADRA1AADRA2BADRA1BTNF | |
| SCHEMBL22435570 | 0.75 | GLA (0.44) | ADRA1DADRA1AADRA2BADRA1BGSK3B | |
| SCHEMBL4095529 | 0.75 | ENPP2 (0.46) | ADRA1DADRA1AADRA2BADRA1BTNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440558-A1 | DIHYDROPYRROLONAPHTYRIDINONE COMPOUNDS AS INHIBITORS OF JAK | Takeda Pharmaceutical Company Limited (JP) | 2012-04-18 | — | — | EP | disclosed |