Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 8/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1705891 | 0.90 | FPR2 (0.54) | FPR2KDM4EGAAMEN1KMT2A | |
| SCHEMBL1706057 | 0.76 | FPR2 (0.41) | FPR2KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL27899572 | 0.76 | FPR2 (0.38) | FPR2KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL27899577 | 0.75 | FPR2 (0.38) | FPR2KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL1706912 | 0.75 | FPR2 (0.52) | FPR2KDM4EHPGDHDAC8HDAC1 | |
| SCHEMBL1706324 | 0.71 | FPR2 (0.54) | FPR2HCRTR2 | |
| SCHEMBL1166587 | 0.68 | FPR2 (0.63) | FPR2KDM4EHCRTR2 | |
| SCHEMBL2331282 | 0.68 | FPR2 (0.63) | FPR2KDM4EHCRTR2 | |
| SCHEMBL1706200 | 0.67 | FPR2 (0.62) | FPR2ALDH1A1HPGDSMN1; SMN2GAA | |
| SCHEMBL27899537 | 0.66 | ADORA2A (0.40) | FPR2KDM4EHPGDHCRTR2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440536-A1 | OXAZOLE AND THIAZOLE DERIVATIVES AS ALX RECEPTOR AGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2012-04-18 | — | — | EP | claimed |
| EP-2440536-A1 | OXAZOLE AND THIAZOLE DERIVATIVES AS ALX RECEPTOR AGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2012-04-18 | — | — | EP | disclosed |