Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.68 |
| ▸ | TP53 | P04637 | 4/20 | 0.68 |
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17063611 | 0.97 | SMN1; SMN2 (0.67) | SMN1; SMN2TP53MAPTTHRBTSHR | |
| SCHEMBL17063600 | 0.93 | SMN1; SMN2 (0.78) | SMN1; SMN2TP53MAPTTHRBTSHR | |
| SCHEMBL17068777 | 0.91 | SMN1; SMN2 (0.58) | SMN1; SMN2TP53MAPTTHRBTSHR | |
| SCHEMBL17063608 | 0.88 | SMN1; SMN2 (0.86) | SMN1; SMN2TP53MAPTTHRBTSHR | |
| SCHEMBL21447098 | 0.88 | SMN1; SMN2 (0.55) | SMN1; SMN2TP53MAPTTHRBTSHR | |
| SCHEMBL17068786 | 0.88 | SMN1; SMN2 (0.57) | SMN1; SMN2TP53MAPTTHRBTSHR | |
| SCHEMBL21434675 | 0.87 | SMN1; SMN2 (0.69) | SMN1; SMN2TP53MAPTTHRBTSHR | |
| SCHEMBL21434739 | 0.86 | TP53 (0.68) | SMN1; SMN2TP53MAPTTHRBTSHR | |
| SCHEMBL17068785 | 0.86 | SMN1; SMN2 (0.64) | SMN1; SMN2TP53MAPTTHRBTSHR | |
| SCHEMBL21434766 | 0.86 | SMN1; SMN2 (0.64) | SMN1; SMN2TP53MAPTTHRBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3116502-A1 | METHODS AND COMPOSITIONS FOR INHIBITING RHO/MRTF-MEDIATED DISEASES AND CONDITIONS | The Regents Of The University Of Michigan (US) | 2017-01-18 | — | — | EP | disclosed |
| WO-2015138326-A1 | METHODS AND COMPOSITIONS FOR INHIBITING RHO/MRTF-MEDIATED DISEASES AND CONDITIONS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2015-09-17 | — | — | WO | disclosed |
| US-20150250769-A1 | METHODS AND COMPOSITIONS FOR INHIBITING RHO/MRTF-MEDIATED DISEASES AND CONDITIONS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2015-09-10 | — | — | US | disclosed |
| US-20150250769-A1 | METHODS AND COMPOSITIONS FOR INHIBITING RHO/MRTF-MEDIATED DISEASES AND CONDITIONS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2015-09-10 | — | — | US | disclosed |
| US-20150250769-A1 | METHODS AND COMPOSITIONS FOR INHIBITING RHO/MRTF-MEDIATED DISEASES AND CONDITIONS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2015-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150250769-A1 | METHODS AND COMPOSITIONS FOR INHIBITING RHO/MRTF-MEDIATED DISEASES AND CONDITIONS | RHOA, ARHGEF1, ARHGEF2 | SMN1; SMN2 3070/4885TP53 1126/4885MAPT 2418/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.