Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.43 |
| ▸ | HRH1 | P35367 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.41 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11706315 | 0.81 | HTR2A (0.45) | HTR2AHRH1LMNATAAR1TDP1 | |
| SCHEMBL17836967 | 0.77 | HTR2A (0.45) | HTR2AHRH1LMNATAAR1TDP1 | |
| SCHEMBL54346 | 0.77 | HTR2A (0.59) | HTR2AHRH1LMNATAAR1TDP1 | |
| SCHEMBL10454608 | 0.75 | CYP3A4 (0.42) | HTR2AHRH1LMNATAAR1TDP1 | |
| SCHEMBL573711 | 0.75 | CYP2C9 (0.49) | HTR2AHRH1LMNATDP1CYP2C9 | |
| SCHEMBL25883772 | 0.75 | HRH1 (0.48) | HTR2AHRH1LMNATAAR1TDP1 | |
| Ammonia Solution, Strong SCHEMBL10389261 | 0.74 | HTR2A (0.56) | HTR2AHRH1LMNATAAR1TDP1 | |
| SCHEMBL29268835 | 0.74 | HTR2A (0.56) | HTR2AHRH1LMNATAAR1TDP1 | |
| Phosphine SCHEMBL28948486 | 0.74 | HTR2A (0.56) | HTR2AHRH1LMNATAAR1TDP1 | |
| SCHEMBL12506256 | 0.74 | HTR2A (0.56) | HTR2AHRH1LMNATAAR1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3113772-A1 | HUMAN PLASMA KALLIKREIN INHIBITORS | Biocryst Pharmaceuticals, Inc. (US) | 2017-01-11 | — | — | EP | disclosed |
| WO-2015134998-A1 | HUMAN PLASMA KALLIKREIN INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2015-09-11 | — | — | WO | disclosed |